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Protein Overview: NKX31_MOUSE

General Information:
Name(s) found: NKX31_MOUSE [Swiss-Prot]
Description(s) found:
Found 32 descriptions.
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  • Homeobox protein Nkx-3.1 OS=Mus musculus GN=Nkx3-1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 237 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
    branching involved in prostate gland morphogenesis [IMP]
    transcription [IEA]
    internal genitalia morphogenesis [TAS]
    multicellular organismal development [IEA]
    negative regulation of cell proliferation [IGI]
    regulation of transcription, DNA-dependent [IDA]
    salivary gland development [IMP]
    branching morphogenesis of a tube [IMP]
    regulation of transcription [IEA]
    epithelial cell proliferation involved in salivary gland morphogenesis [IMP]
    pharyngeal system development [IEPLink to PubMed article]
    negative regulation of insulin-like growth factor receptor signaling pathway [IDA]
    heart development [IEPLink to PubMed article]
    urogenital system development [TAS]
    somitogenesis [IEPLink to PubMed article]
    negative regulation of epithelial cell proliferation [IMP]
    prostate gland development [TAS]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IDA]
    protein binding [IPI]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]
    transcription factor binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRVAEPREP RVEAGGRSPW AAPPTQSKRL TSFLIQDILR DRAERHGGHS GNPQHSPDPR  60
   61 RDSAPEPDKA GGRGVAPEDP PSIRHSPAET PTEPESDAHF ETYLLDCEHN PGDLASAPQV 120
  121 TKQPQKRSRA AFSHTQVIEL ERKFSHQKYL SAPERAHLAK NLKLTETQVK IWFQNRRYKT 180
  181 KRKQLSEDLG VLEKNSPLSL PALKDDSLPS TSLVSVYTSY PYYPYLYCLG SWHPSFW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] deduced N/A No confident structure predictions are available.
    2 View Details [67..237] PSI-BLAST 22.522879 Homeobox protein hox-b1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle