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Protein Overview: EXOS2_MOUSE

General Information:
Name(s) found: EXOS2_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|74188234|dbj|BAE25788.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|74184951|dbj|BAE39092.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|62900370|sp|Q8VBV3.1|EXOS2_MOUSE RecName: Full=Exosome complex exonuclease RRP4; AltName: Full=Ribosomal RNA-processing protein 4; AltName: Full=Exosome component 2 [NCBI NR]
  • gi|21450259|ref|NP_659135.1| exosome component 2 [Mus musculus] [NCBI NR]
  • gi|18256844|gb|AAH21807.1| Exosome component 2 [Mus musculus] [NCBI NR]
  • gi|18204420|gb|AAH21485.1| Exosome component 2 [Mus musculus] [NCBI NR]
  • gi|148676565|gb|EDL08512.1| exosome component 2 [Mus musculus] [NCBI NR]
  • gi|123236042|emb|CAM26562.1| exosome component 2 [Mus musculus] [NCBI NR]
  • Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):2-31938497 Hypothetical 32.6 kDa protein [hmr_yeast5_DM3-1_pombe.fasta]
  • exosome component 2; homolog of Yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease [HMR_022704-rand.fasta]
  • Exosome complex exonuclease RRP4 [ipi.MOUSE.v3.06.fasta]
  • exosome component 2 [Mus musculus]gi|18256844|gb|AAH21807.1| Exosome component 2 [Mus musculus]gi|18204420|gb|AAH21485.1| Exosome component 2 [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Exosome complex exonuclease RRP4 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_144886) hypothetical protein MGC30456 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • exosome component 2 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Exosome complex exonuclease RRP4 (Ribosomal RNA-processing protein 4) (Exosome component 2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Exosome component 2 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 EXOSOME COMPONENT 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc2 Exosome complex exonuclease RRP4 [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc2 Exosome complex exonuclease RRP4 ENSMUSG00000039356 IPI00751004 IPI00121437 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • exosome complex exonuclease RRP4 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00121437.1|SWISS-PROT:Q8VBV3|TREMBL:Q3TKQ3|ENSEMBL:ENSMUSP00000043519|REFSEQ:NP_659135|VEGA:OTTMUSP00000013001 Tax_Id=10090 Gene_Symbol=Exosc2 Exosome complex exonuclease RRP4 [ipi.MOUSE.fasta.20090209]
  • Exosome complex exonuclease RRP4 OS=Mus musculus GN=Exosc2 [011711_HMR.fasta]
  • Exosome complex exonuclease RRP4 OS=Mus musculus GN=Exosc2 PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 [122011_mus.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc2 Exosome complex component RRP4 [EBI-IPI_mouse_2_08-18-2011_reversed.fasta]
  • Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 PE=2 SV=1 [uniprot-mouse-120502.fasta]
  • sp|Q8VBV3|EXOS2_MOUSE Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • tr|Q3TKQ3|Q3TKQ3_MOUSE Exosome component 2 OS=Mus musculus GN=Exosc2 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • Exosome component 2 OS=Mus musculus GN=Exosc2 PE=2 SV=1 [mouse-uniprot-290313-contam.fasta]
  • Isoform of Q8VBV3, Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 PE=1 SV=1 [MOUSE.fasta.20160308]
    • Organism: Mus musculus
    Length: 293 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEMRLPKA RKPLSESLGR DSKKHLVVPG DTITTDTGFM RGHGTYMGEE KLIASVAGSV  60
   61 ERVNKLICVK ALKTRYNGEV GDIVVGRITE VQQKRWKVET NSRLDSVLLL SSMNLPGGEL 120
  121 RRRSAEDELA MRGFLQEGDL ISAEVQAVFS DGAVSLHTRS LKYGKLGQGV LVQVSPSLVK 180
  181 RQKTHFHDLP CGASVILGNN GFIWIYPTPE HKDEDAGGFI ANLEPVALSD REVISRLRNC 240
  241 VVLLVTQRMM LFDTSILYCY EASLAHQIKD ILKPEVMEEI MLETRQRLLD QEG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..293] PSI-BLAST 76.30103 No description for 2nn6H was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.18414740305744 bayes_pls_golite062009
  • exoribonuclease activity
    		•  4.57899887224013 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  4.54136587416505 bayes_pls_golite062009
  • ribonuclease activity
    		•  4.53127626527286 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.89236528662255 bayes_pls_golite062009
  • mRNA binding
    		•  3.82977088614136 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.68444148122352 bayes_pls_golite062009
  • structural molecule activity
    		•  3.54418030121155 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  3.40736445988244 bayes_pls_golite062009
  • binding
    		•  2.8667878224392 bayes_pls_golite062009
    		• 1.63970610538963 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.62417180482862 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.55351486913613 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.43703138180882 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.42151567812515 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • exonuclease activity
    		•  1.25488463068335 bayes_pls_golite062009
  • DNA binding
    		•  1.20852534725468 bayes_pls_golite062009
  • exoribonuclease II activity
    		•  1.18248519339188 bayes_pls_golite062009
  • protein binding
    		•  0.934192915895039 bayes_pls_golite062009
  • hydrolase activity
    		•  0.704891843968224 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.489176583045793 bayes_pls_golite062009
  • transcription factor activity
    		•  0.386248501195543 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32222928997178 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.30467150200016 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.1069917291606 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle