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Protein Overview: FBpp0292486

General Information:
Name(s) found: FBpp0292486 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • type=protein; loc=2R:complement(10834021..10834108,10834684..10834805,10835147..10835341,10835399..10836355,10836422..10836507,10836879..10836929,10838192..10838273); ID=FBpp0292486; name=aPKC-PB; parent=FBgn0261854,FBtr0303429; dbxref=FlyBase:FBpp0292486,FlyBase:FBpp0110294,FlyBase_Annotation_IDs:CG10261-PB,FlyBase_Annotation_IDs:CG42783-PB,REFSEQ:NP_001036544,GB_protein:ABI31093,FlyMine:FBpp0292486,modMine:FBpp0292486; MD5=9de9313a488e61ea14447c305d441113; length=526; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 526 amino acids

    Gene Ontology:
    Cellular Component: subapical complex [TAS]
    cytoplasm [NAS]
    cell cortex [TAS]
    apical cortex [IDA][NAS]
    apical plasma membrane [NAS][TAS]
    Biological Process: cell-cell junction assembly [NAS]
    germarium-derived oocyte fate determination [IMP]
    establishment or maintenance of cell polarity [NAS]
    positive regulation of neuroblast proliferation [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    memory [IMP]
    sensory organ development [IMP]
    oocyte anterior/posterior axis specification [IGI]
    establishment or maintenance of neuroblast polarity [NAS]
    oocyte axis specification [TAS]
    synapse assembly [IMP]
    intracellular signaling pathway [IEA]
    asymmetric protein localization involved in cell fate determination [IPI]
    zonula adherens assembly [NAS][TAS]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP][NAS][TAS]
    apical protein localization [NAS]
    maintenance of cell polarity [IMP]
    morphogenesis of a polarized epithelium [TAS]
    asymmetric neuroblast division [IGI]
    establishment or maintenance of polarity of embryonic epithelium [NAS]
    Molecular Function: ATP binding [IEA]
    zinc ion binding [IEA]
    protein binding [IPI][ISS]
    protein serine/threonine kinase activity [IEA][NAS]
    protein kinase C activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIWSGFCEA AQIYSTQTAT FMSGGASLFP NVPQAPGLSC DGEDRSIYRR GARRWRKLYR  60
   61 VNGHIFQAKR FNRRAFCAYC QDRIWGLGRQ GFKCIQCKLL VHKKCHKLVQ KHCTDQPEPL 120
  121 VKERAEESSD PIPVPLPPLP YEAMSGGAEA CETHDHAHIV APPPPEDPLE PGTQRQYSLN 180
  181 DFELIRVIGR GSYAKVLMVE LRRTRRIYAM KVIKKALVTD DEDIDWVQTE KHVFETASNH 240
  241 PFLVGLHSCF QTPSRLFFVI EFVRGGDLMY HMQRQRRLPE EHARFYAAEI SLALNFLHEK 300
  301 GIIYRDLKLD NVLLDHEGHI KLTDYGMCKE GIRPGDTTST FCGTPNYIAP EILRGEDYGF 360
  361 SVDWWALGVL LYEMLAGRSP FDLAGASENP DQNTEDYLFQ VILEKTIRIP RSLSVRAASV 420
  421 LKGFLNKNPA DRLGCHRESA FMDIVSHPFF KNMDWELIAQ KEVQPPYIPN IDTGDPYVTS 480
  481 NFDVQFTQEP AVLTPDDPHV IDNIDQSEFE GFEYVNPLLM SLEDCV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..460] PSI-BLAST 43.69897 Carboxyl-terminal src kinase (csk)
    2 View Details [461..526] PSI-BLAST 95.154902 Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle