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Protein Overview: IL11_MOUSE

General Information:
Name(s) found: IL11_MOUSE [Swiss-Prot]
Description(s) found:
Found 29 descriptions.
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  • Interleukin-11 OS=Mus musculus GN=Il11 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 199 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IEA]
    extracellular region [IEA]
    Biological Process: positive regulation of cell proliferation [IDA]
    positive regulation of MAPKKK cascade [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    negative regulation of hormone secretion [UNKNOWN]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN]
    Molecular Function: growth factor activity [ISS]
    interleukin-11 receptor binding [IPI]
    cytokine activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM  60
   61 RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK 120
  121 TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG 180
  181 LHLTLDWAVR GLLLLKTRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] FFAS03 3.81 CRYSTAL STRUCTURE OF CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  5.32452883674861 bayes_pls_golite062009
  • receptor binding
    		•  4.89539487046829 bayes_pls_golite062009
  • growth factor activity
    		•  4.51160000079914 bayes_pls_golite062009
  • cytokine activity
    		•  4.02056239338048 bayes_pls_golite062009
  • protein binding
    		•  3.06595785728688 bayes_pls_golite062009
  • binding
    		•  2.34498077824037 bayes_pls_golite062009
  • hormone activity
    		•  2.11743506244156 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  1.963916704748 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  1.23610537118032 bayes_pls_golite062009
  • catalytic activity
    		•  0.263255675478865 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0253518560873331 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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