YRC Public Data Repository - Protein Structure Prediction

Protein:	IL11_MOUSE
Organism:	Mus musculus
Length:	199 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL11_MOUSE.

Description	E-value	Query Range	Subject Range
IL11_RAT - Interleukin-11 OS=Rattus norvegicus GN=Il11 PE=2 SV=1	287.0	[0..1]	[199..1]
gi\|74215582 - gi\|74215582\|dbj\|BAE21410.1\| unnamed protein product [Mus musculus]	283.0	[0..4]	[199..23]
IL11_MACFA - Interleukin-11 OS=Macaca fascicularis GN=IL11 PE=2 SV=1	257.0	[0..1]	[199..1]
gi\|114679121 - gi\|114679121\|ref\|XP_001136017.1\| PREDICTED: similar to adipogenesis inhibitory factor [Pan troglodyt...	246.0	[0..1]	[199..155]
gi\|60816503, gi\|... - gi\|61359587\|gb\|AAX41739.1\| interleukin 11 [synthetic construct], gi\|61358351\|gb\|AAX41553.1\| interleu... ENSPTRT00000021439 - null IL11 - interleukin 11	245.0	[0..1]	[199..1]
gi\|61369673, gi\|... - gi\|61369673\|gb\|AAX43370.1\| interleukin 11 [synthetic construct], gi\|61368452\|gb\|AAX43182.1\| interleu...	237.0	[0..1]	[191..1]
gi\|73947466 - gi\|73947466\|ref\|XP_854055.1\| PREDICTED: similar to interleukin 11 precursor [Canis familiaris] tr\|M3W4F9\|M3W4F9... - Interleukin 11 OS=Felis catus GN=IL11 PE=4 SV=1	214.0	[0..1]	[199..1]
gi\|76642508 - gi\|76642508\|ref\|XP_876126.1\| PREDICTED: similar to interleukin 11 precursor [Bos taurus]	112.0	[0..89]	[199..212]

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Predicted Domain #1

Region A:
Residues: [1-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM  60
   61 RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK 120
  121 TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG 180
  181 LHLTLDWAVR GLLLLKTRL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.81
Match:	1bgcA
Description:	CRYSTAL STRUCTURE OF CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytokine receptor binding	5.32452883674861	bayes_pls_golite062009
receptor binding	4.89539487046829	bayes_pls_golite062009
growth factor activity	4.51160000079914	bayes_pls_golite062009
cytokine activity	4.02056239338048	bayes_pls_golite062009
protein binding	3.06595785728688	bayes_pls_golite062009
binding	2.34498077824037	bayes_pls_golite062009
hormone activity	2.11743506244156	bayes_pls_golite062009
interleukin-6 receptor binding	1.963916704748	bayes_pls_golite062009
interleukin-10 receptor binding	1.23610537118032	bayes_pls_golite062009
catalytic activity	0.263255675478865	bayes_pls_golite062009
transcription regulator activity	0.0253518560873331	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: