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Protein Overview: VHL

General Information:
Name(s) found: VHL [HGNC (HUGO)]
Description(s) found:
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  • gi|4507891|ref|NP_000542.1| von Hippel-Lindau tumor suppressor isoform 1 [Homo sapiens] [NCBI NR]
  • gi|4033778|sp|P40337.2|VHL_HUMAN RecName: Full=Von Hippel-Lindau disease tumor suppressor; AltName: Full=pVHL; AltName: Full=Protein G7 [NCBI NR]
  • gi|2282064|gb|AAB64200.1| von Hippel-Lindau tumor suppressor; VHL protein; pVHL [Homo sapiens] [NCBI NR]
  • gi|189055157|dbj|BAG38142.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119584470|gb|EAW64066.1| von Hippel-Lindau tumor suppressor, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119584468|gb|EAW64064.1| von Hippel-Lindau tumor suppressor, isoform CRA_a [Homo sapiens] [NCBI NR]
  • von Hippel-Lindau tumor suppressor [HGNC (HUGO)]
  • Von Hippel-Lindau disease tumor suppressor OS=Homo sapiens GN=VHL PE=1 SV=2 [Swiss-Prot]
  • Splice isoform 1 of P40337 [hmr_yeast5_DM3-1_pombe.fasta]
  • von Hippel-Lindau tumor suppressor isoform 1; elongin binding protein [HMR_022704.fasta]
  • von Hippel-Lindau tumor suppressor isoform 1 [Homo sapiens]gi|2282064|gb|AAB64200.1| von Hippel-Lindau tumor suppressor; VHL protein; pVHL [Homo sapiens]gi|4033778|sp|P40337|VHL_HUMAN Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) [nrdb_11152004_Chlamydomonas]
  • Von Hippel-Lindau disease tumor suppressor (pVHL) (G7 protein) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Von Hippel-Lindau disease tumor suppressor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000551) elogin binding protein; von Hippel-Lindau tumor suppressor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • von Hippel-Lindau tumor suppressor isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • von Hippel-Lindau tumor suppressor isoform 1; elongin binding protein [Homo sapiens] [HumanGallus06162005.fasta]
  • Von Hippel-Lindau disease tumor suppressor (pVHL) (Protein G7) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • von Hippel-Lindau tumor suppressor, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • von Hippel-Lindau tumor suppressor; VHL protein; pVHL [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Von Hippel-Lindau disease tumor suppressor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Von Hippel-Lindau disease tumor suppressor; AltName: Full=pVHL; AltName: Full=Protein G7 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=VHL Isoform 1 of Von Hippel-Lindau disease tumor suppressor [human-ipi-250309-contam.fasta]
  • IPI:IPI00027969.1|SWISS-PROT:P40337-1|ENSEMBL:ENSP00000256474|REFSEQ:NP_000542|H-INV:HIT000192281|VEGA:OTTHUMP00000158850;OTTHUMP00000170191 Tax_Id=9606 Gene_Symbol=VHL Isoform 1 of Von Hippel-Lindau disease tumor suppressor [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=VHL Isoform 1 of Von Hippel-Lindau disease tumor suppressor ENSG00000134086 IPI00221186 IPI00027969 IPI00792496 IPI00336024 [drosphohumanreversed.fasta]
  • von Hippel-Lindau disease tumor suppressor isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P40337;B2RE45;Q13599;Q6PDA9; RecName: Full=Von Hippel-Lindau disease tumor suppressor; AltName: Full=pVHL; AltName: Full=Protein G7; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Von Hippel-Lindau disease tumor suppressor OS=Homo sapiens GN=VHL [011711_HMR.fasta]
  • GeneSymbol=VHL Synonyms=HRCA1|RCA1|VHL1 von Hippel-Lindau disease tumor suppressor isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00027969.1|SWISS-PROT:P40337-1|TREMBL:A4ZYX2|ENSEMBL:ENSP00000256474|REFSEQ:NP_000542|H-INV:HIT000192281|VEGA:OTTHUMP00000158850 Tax_Id=9606 Gene_Symbol=VHL Isoform 1 of Von Hippel-Lindau disease tumor suppressor [ipi.HUMAN.20110912.fasta]
  • Von Hippel-Lindau disease tumor suppressor GN=VHL [Doctor+uniprot-HUMAN-120911.fasta]
  • von Hippel-Lindau tumor suppressor, isoform CRA_a OS=Homo sapiens GN=VHL PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR  60
   61 PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 120
  121 DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI 180
  181 VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] MSA 1.012986 View MSA. No confident structure predictions are available.
    2 View Details [60..213] PSI-BLAST 79.0 VHL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  3.41909857804058 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.22022352763801 bayes_pls_golite062009
  • binding
    		•  2.41295334316774 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.3720830747925 bayes_pls_golite062009
  • protein binding
    		•  2.1782543635871 bayes_pls_golite062009
  • transcription factor binding
    		•  2.06418606532911 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.0718313791207 bayes_pls_golite062009
  • catalytic activity
    		•  0.334765053110546 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle