YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: VHL
Organism: Homo sapiens
Length: 213 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VHL.

Description E-value Query
Range
Subject
Range
gi|197102444 - gi|197102444|ref|NP_001126390.1| von Hippel-Lindau tumor suppressor [Pongo abelii]
gi|55731296 - gi|55731296|emb|CAH92362.1| hypothetical protein [Pongo abelii]
2.0E-96 [1..213] [1..213]
VHL_CANLF - Von Hippel-Lindau disease tumor suppressor OS=Canis lupus familiaris GN=VHL PE=2 SV=1
3.0E-82 [1..212] [1..212]
gi|21730827 - gi|21730827|pdb|1LQB|C Chain C, Crystal Structure Of A Hydroxylated Hif-1 Alpha Peptide Bound To The...
2.0E-77 [52..213] [1..162]
VHL_RAT - Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl PE=1 SV=1
gi|1245912 - gi|1245912|gb|AAB35675.1| von Hippel-Lindau tumor suppressor gene homolog [Rattus sp.]
3.0E-76 [38..213] [6..179]
gi|76648503 - gi|76648503|ref|XP_613870.2| PREDICTED: similar to Von Hippel-Lindau disease tumor suppressor (pVHL)...
8.0E-76 [49..211] [24..186]
gi|2143464, gi|9... - gi|913328|gb|AAB33363.1| von Hippel-Lindau disease gene [Mus sp.], gi|2143464|pir||I52731 gene mVHLh...
VHL_MOUSE - Von Hippel-Lindau disease tumor suppressor OS=Mus musculus GN=Vhl PE=1 SV=1
2.0E-74 [38..213] [6..179]

Back

Predicted Domain #1
Region A:
Residues: [1-59]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [60-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPVLRSVNSR EPSQVIFCNR SPRVVLPVWL NFDGEPQPYP TLPPGTGRRI HSYRGHLWLF  60
   61 RDAGTHDGLL VNQTELFVPS LNVDGQPIFA NITLPVYTLK ERCLQVVRSL VKPENYRRLD 120
  121 IVRSLYEDLE DHPNVQKDLE RLTQERIAHQ RMGD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.0
Match: 1lqbC
Description: VHL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 3.41909857804058 bayes_pls_golite062009
small conjugating protein ligase activity 3.22022352763801 bayes_pls_golite062009
binding 2.41295334316774 bayes_pls_golite062009
acid-amino acid ligase activity 2.3720830747925 bayes_pls_golite062009
protein binding 2.1782543635871 bayes_pls_golite062009
transcription factor binding 2.06418606532911 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 1.0718313791207 bayes_pls_golite062009
catalytic activity 0.334765053110546 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle