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Protein Overview: XRCC5

General Information:
Name(s) found: XRCC5 [HGNC (HUGO)]
Description(s) found:
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  • pir||A32626 Ku antigen 80K chain - human [NCBI NR]
  • gi|66267600|gb|AAH95442.1| X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [Homo sapiens] [NCBI NR]
  • gi|307094|gb|AAA36154.1| Ku (p70/p80) subunit [NCBI NR]
  • gi|307093|gb|AAA59475.1| Ku antigen [Homo sapiens] [NCBI NR]
  • gi|17512093|gb|AAH19027.1| X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [Homo sapiens] [NCBI NR]
  • gi|125731|sp|P13010.3|KU86_HUMAN RecName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=Ku [NCBI NR]
  • gi|119590968|gb|EAW70562.1| X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|109821670|gb|ABG46942.1| X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) [Homo sapiens] [NCBI NR]
  • gi|10863945|ref|NP_066964.1| ATP-dependent DNA helicase II [Homo sapiens] [NCBI NR]
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [HGNC (HUGO)]
  • X-ray repair cross-complementing protein 5 OS=Homo sapiens GN=XRCC5 PE=1 SV=3 [Swiss-Prot]
  • ATP-dependent DNA helicase 2 subunit 2 OS=Homo sapiens GN=XRCC5 PE=1 SV=3 [Swiss-Prot]
  • ATP-dependant DNA helicase II [hmr_yeast5_DM3-1_pombe.fasta]
  • ATP-dependant DNA helicase II; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair, complementing defective, repair in Chinese hamster; DNA repair protein XRCC5; Ku86 a [HMR_022704.fasta]
  • ATP-dependent DNA helicase II; DNA repair protein XRCC5; X-ray repair, complementing defective, repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD); Ku86 a [Human2242005.fasta]
  • ATP-dependent DNA helicase II [Homo sapiens]gi|17512093|gb|AAH19027.1| ATP-dependant DNA helicase II [Homo sapiens]gi|88066|pir||A32626 Ku antigen 80K chain - humangi|307093|gb|AAA59475.1| Ku antigengi|125731|sp|P13010|KU86_HUMAN ATP-dependent DNA hel [nrdb_11152004_Chlamydomonas]
  • ATP-dependent DNA helicase II, 80 kDa subunit (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 85 kDa subunit) (CTCBF) (CTC85) (Nuclear factor IV) (DNA-repair protei [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_021141) ATP-dependant DNA helicase II; X-ray repair, complementing defective, repair in Chinese hamster; DNA repair protein XRCC5 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ATP-dependent DNA helicase II [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 ATP-dependent DNA helicase II [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ATP-dependent DNA helicase 2 subunit 2 (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (86 kDa subunit of Ku antigen) (Ku86) (Ku80) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ku antigen [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ku (p70/p80) subunit [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 ATP-DEPENDENT DNA HELICASE II [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=XRCC5 ATP-dependent DNA helicase 2 subunit 2 [human-ipi-250309-contam.fasta]
  • ATP-dependent DNA helicase 2 subunit 2 (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85 [nr-271106-contam.fasta]
  • IPI:IPI00220834.8|SWISS-PROT:P13010|TREMBL:Q53T09|ENSEMBL:ENSP00000329528;ENSP00000375977;ENSP00000375978|REFSEQ:NP_066964|H-INV:HIT000195394|VEGA:OTTHUMP00000164061;OTTHUMP00000206791 Tax_Id=9606 Gene_Symbol=XRCC5 ATP-dependent DNA helicase 2 subunit 2 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 ATP-dependent DNA helicase 2 subunit 2 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=XRCC5 ATP-dependent DNA helicase 2 subunit 2 ENSG00000079246 IPI00012911 IPI00220834 [drosphohumanreversed.fasta]
  • ATP-dependent DNA helicase 2 subunit 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P13010;A8K3X5;Q0Z7V0;Q4VBQ5;Q53HH7;Q7M4N0;Q9UCQ0;Q9UCQ1; RecName: Full=X-ray repair cross-complementing protein 5; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); AltName: Full=ATP-dependent DNA helicase 2 subunit 2; AltName: Full=ATP-dependent DNA helicase II 80 kDa subunit; AltName: Full=Lupus Ku autoantigen protein p86; AltName: Full=86 kDa subunit of Ku antigen; AltName: Full=Ku86; AltName: Full=Ku80; AltName: Full=Thyroid-lupus autoantigen; AltName: Full=CTC box-binding factor 85 kDa subunit; AltName: Full=Nuclear factor IV; AltName: Full=DNA repair protein XRCC5; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • X-ray repair cross-complementing protein 5 OS=Homo sapiens GN=XRCC5 [011711_HMR.fasta]
  • IPI:IPI00220834.8|SWISS-PROT:P13010|TREMBL:Q53T09;Q53TC2|ENSEMBL:ENSP00000329528;ENSP00000375977;ENSP00000375978|REFSEQ:NP_066964|H-INV:HIT000195394|VEGA:OTTHUMP00000164061;OTTHUMP00000206791 Tax_Id=9606 Gene_Symbol=XRCC5 ATP-dependent DNA helicase 2 subunit 2 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=XRCC5 Synonyms=FLJ39089|KARP-1|KARP1|KU80|KUB2|Ku86|NFIV X-ray repair cross-complementing protein 5 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00220834.8|SWISS-PROT:P13010|TREMBL:Q53T09;Q53TC2|ENSEMBL:ENSP00000375977;ENSP00000375978|REFSEQ:NP_066964|H-INV:HIT000195394|VEGA:OTTHUMP00000164061 Tax_Id=9606 Gene_Symbol=XRCC5 X-ray repair cross-complementing protein 5 [ipi.HUMAN.20110912.fasta]
  • X-ray repair cross-complementing protein 5 GN=XRCC5 [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=XRCC5 X-ray repair cross-complementing protein 5 [human-ipi-270911-contam-BSA.fasta]
    • Organism: Homo sapiens
    Length: 732 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRSGNKAAV VLCMDVGFTM SNSIPGIESP FEQAKKVITM FVQRQVFAEN KDEIALVLFG  60
   61 TDGTDNPLSG GDQYQNITVH RHLMLPDFDL LEDIESKIQP GSQQADFLDA LIVSMDVIQH 120
  121 ETIGKKFEKR HIEIFTDLSS RFSKSQLDII IHSLKKCDIS LQFFLPFSLG KEDGSGDRGD 180
  181 GPFRLGGHGP SFPLKGITEQ QKEGLEIVKM VMISLEGEDG LDEIYSFSES LRKLCVFKKI 240
  241 ERHSIHWPCR LTIGSNLSIR IAAYKSILQE RVKKTWTVVD AKTLKKEDIQ KETVYCLNDD 300
  301 DETEVLKEDI IQGFRYGSDI VPFSKVDEEQ MKYKSEGKCF SVLGFCKSSQ VQRRFFMGNQ 360
  361 VLKVFAARDD EAAAVALSSL IHALDDLDMV AIVRYAYDKR ANPQVGVAFP HIKHNYECLV 420
  421 YVQLPFMEDL RQYMFSSLKN SKKYAPTEAQ LNAVDALIDS MSLAKKDEKT DTLEDLFPTT 480
  481 KIPNPRFQRL FQCLLHRALH PREPLPPIQQ HIWNMLNPPA EVTTKSQIPL SKIKTLFPLI 540
  541 EAKKKDQVTA QEIFQDNHED GPTAKKLKTE QGGAHFSVSS LAEGSVTSVG SVNPAENFRV 600
  601 LVKQKKASFE EASNQLINHI EQFLDTNETP YFMKSIDCIR AFREEAIKFS EEQRFNNFLK 660
  661 ALQEKVEIKQ LNHFWEIVVQ DGITLITKEE ASGSSVTAEE AKKFLAPKDK PSGDTAAVFE 720
  721 EGGDVDDLLD MI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..558] PSI-BLAST 171.0 Ku80 subunit
    2 View Details [559..732] PSI-BLAST 51.30103 Three-dimensional structure of Ku80 CTD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • single-stranded DNA-dependent ATP-dependent DNA helicase activity
    		•  4.34918548316444 bayes_pls_golite062009
  • single-stranded DNA-dependent ATPase activity
    		•  4.01349229451071 bayes_pls_golite062009
  • DNA helicase activity
    		•  3.77011551449253 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • protein binding
    		•  2.58357303743968 bayes_pls_golite062009
  • promoter binding
    		•  2.1752902301709 bayes_pls_golite062009
  • transcription activator activity
    		•  1.52393053398849 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27592771659837 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • protein complex binding
    		•  0.94234534987624 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.73404855126602 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655463239522058 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.64812784969409 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • DNA binding
    		•  0.496246846559375 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • receptor binding
    		•  0.234020194580985 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.233577421367532 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
  • identical protein binding
    		•  0.125363466534611 bayes_pls_golite062009
  • collagen binding
    		•  0.113837148027681 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle