Protein Overview: CST4

General Information:
Name(s) found:	CST4 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|9971054\|emb\|CAC07196.1\| cystatin S [Homo sapiens] [NCBI NR] gi\|50960167\|gb\|AAH74953.1\| Cystatin S [Homo sapiens] [NCBI NR] gi\|49904748\|gb\|AAH74952.1\| Cystatin S [Homo sapiens] [NCBI NR] gi\|4503109\|ref\|NP_001890.1\| cystatin S precursor [Homo sapiens] [NCBI NR] gi\|41350860\|gb\|AAH65714.1\| Cystatin S [Homo sapiens] [NCBI NR] gi\|399336\|sp\|P01036.3\|CYTS_HUMAN RecName: Full=Cystatin-S; AltName: Full=Cystatin-4; AltName: Full=Salivary acidic protein 1; AltName: Full=Cystatin-SA-III; Flags: Precursor [NCBI NR] gi\|30366\|emb\|CAA38478.1\| cystain S [Homo sapiens] [NCBI NR] gi\|261714\|gb\|AAB24493.1\| cystatin S precursor [Homo sapiens] [NCBI NR] pir\|\|UDHUP1 cystatin S precursor - human [NCBI NR] gi\|13021875\|gb\|AAK11571.1\|AF319565_1 cystatin S precursor [Homo sapiens] [NCBI NR] gi\|119630540\|gb\|EAX10135.1\| cystatin S [Homo sapiens] [NCBI NR] cystatin S [HGNC (HUGO)] Cystatin-S OS=Homo sapiens GN=CST4 PE=1 SV=3 [Swiss-Prot] Cystatin S precursor [hmr_yeast5_DM3-1_pombe.fasta] cystatin S precursor; cystatin 4 [HMR_022704.fasta] cystatin S precursor [Homo sapiens]gi\|41350860\|gb\|AAH65714.1\| Cystatin S, precursor [Homo sapiens]gi\|49904748\|gb\|AAH74952.1\| Cystatin S, precursor [Homo sapiens]gi\|50960167\|gb\|AAH74953.1\| Cystatin S, precursor [Homo sapiens]gi\|9971054\|emb\|CAC07196.1\| [nrdb_11152004_Chlamydomonas] Cystatin S precursor (Salivary acidic protein 1) (Cystatin SA-III) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Cystatin S precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_001899) cystatin S precursor; cystatin 4 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] cystatin S precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] cystatin S precursor; cystatin 4 [Homo sapiens] [HumanGallus06162005.fasta] Cystatin-S precursor (Cystatin-4) (Salivary acidic protein 1) (Cystatin-SA-III) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] cystatin S [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Cystatin S [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] cystain S [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 CYSTATIN S PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=CST4 Cystatin-S [human-ipi-250309-contam.fasta] CST4 [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00032294.1\|SWISS-PROT:P01036\|ENSEMBL:ENSP00000217423\|REFSEQ:NP_001890\|H-INV:HIT000261995\|VEGA:OTTHUMP00000030443 Tax_Id=9606 Gene_Symbol=CST4 Cystatin-S [ipi.HUMAN.fasta.20090807] Tax_Id=9606 Cystatin-S precursor [IPI_human_3.26.fasta] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=CST4 Cystatin-S precursor ENSG00000101441 IPI00032294 [drosphohumanreversed.fasta] Tax_Id=9606 Gene_Symbol=CST4 Cystatin-S precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta] cystatin-S precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] P01036;Q9UBI5;Q9UCS9; RecName: Full=Cystatin-S; AltName: Full=Cystatin-4; AltName: Full=Salivary acidic protein 1; AltName: Full=Cystatin-SA-III; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Cystatin-S OS=Homo sapiens GN=CST4 [011711_HMR.fasta] GeneSymbol=CST4 Synonyms=MGC71923 cystatin-S precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] Cystatin-S GN=CST4 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	141 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MARPLCTLLL LMATLAGALA SSSKEENRII PGGIYDADLN DEWVQRALHF AISEYNKATE 60 61 DEYYRRPLQV LRAREQTFGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120 121 EIYEVPWEDR MSLVNSRCQE A

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..141]	PSI-BLAST	37.522879	Cystatin C

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
peptidase inhibitor activity	4.09256652564756	bayes_pls_golite062009
endopeptidase inhibitor activity	4.06934751275178	bayes_pls_golite062009
metalloendopeptidase inhibitor activity	3.91155159929014	bayes_pls_golite062009
metalloenzyme regulator activity	3.91155159929014	bayes_pls_golite062009
metalloenzyme inhibitor activity	3.91155159929014	bayes_pls_golite062009
protease binding	3.73826839062329	bayes_pls_golite062009
enzyme inhibitor activity	3.46240889348325	bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity	2.23436900482885	bayes_pls_golite062009
binding	1.98021211698364	bayes_pls_golite062009
protein binding	1.87374230443113	bayes_pls_golite062009
enzyme binding	1.6342022584305	bayes_pls_golite062009
beta-amyloid binding	0.57867775643241	bayes_pls_golite062009
enzyme regulator activity	0.479748849334581	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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