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View Structure Prediction Details

Protein: CST4
Organism: Homo sapiens
Length: 141 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CST4.

Description E-value Query
Range
Subject
Range
gi|192912, gi|109759 - gi|192912|gb|AAA63298.1| cystatin C, pir||A36163 cystatin C precursor - mouse
2.0E-41 [1..141] [1..140]
gi|109093125 - gi|109093125|ref|XP_001097284.1| PREDICTED: cystatin SA [Macaca mulatta]
1.0E-39 [1..141] [1..141]
gi|58081 - gi|58081|emb|CAA31253.1| ompA - cystatin C fusion preprotein (AA -21 to 120) [synthetic construct]
2.0E-39 [1..141] [1..141]
gi|55651412 - gi|55651412|ref|XP_514555.1| PREDICTED: similar to Cystatin SA precursor (Cystatin S5) isoform 3 [Pa...
3.0E-39 [1..141] [1..141]
gi|18204598, gi|... - gi|19882251|ref|NP_001889.2| cystatin SN precursor [Homo sapiens], gi|18204598|gb|AAH21225.1| Cystat...
4.0E-38 [21..141] [21..141]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARPLCTLLL LMATLAGALA SSSKEENRII PGGIYDADLN DEWVQRALHF AISEYNKATE  60
   61 DEYYRRPLQV LRAREQTFGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 120
  121 EIYEVPWEDR MSLVNSRCQE A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.522879
Match: 1g96A
Description: Cystatin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase inhibitor activity 4.09256652564756 bayes_pls_golite062009
endopeptidase inhibitor activity 4.06934751275178 bayes_pls_golite062009
metalloendopeptidase inhibitor activity 3.91155159929014 bayes_pls_golite062009
metalloenzyme regulator activity 3.91155159929014 bayes_pls_golite062009
metalloenzyme inhibitor activity 3.91155159929014 bayes_pls_golite062009
protease binding 3.73826839062329 bayes_pls_golite062009
enzyme inhibitor activity 3.46240889348325 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 2.23436900482885 bayes_pls_golite062009
binding 1.98021211698364 bayes_pls_golite062009
protein binding 1.87374230443113 bayes_pls_golite062009
enzyme binding 1.6342022584305 bayes_pls_golite062009
beta-amyloid binding 0.57867775643241 bayes_pls_golite062009
enzyme regulator activity 0.479748849334581 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle