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Protein Overview: TIMP1

General Information:
Name(s) found: TIMP1 [HGNC (HUGO)]
Description(s) found:
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  • pir||ZYHUEP metalloproteinase tissue inhibitor 1 precursor [validated] - human [NCBI NR]
  • gi|57210053|emb|CAI42465.1| TIMP metallopeptidase inhibitor 1 [Homo sapiens] [NCBI NR]
  • gi|49456917|emb|CAG46779.1| TIMP1 [Homo sapiens] [NCBI NR]
  • gi|47115213|emb|CAG28566.1| TIMP1 [Homo sapiens] [NCBI NR]
  • gi|4507509|ref|NP_003245.1| tissue inhibitor of metalloproteinase 1 precursor [Homo sapiens] [NCBI NR]
  • gi|4261709|gb|AAD14009.1|S68252_1 metalloproteinase inhibitor [Homo sapiens] [NCBI NR]
  • gi|37183|emb|CAA26902.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|225633|prf||1308125A metalloproteinase inhibitor [NCBI NR]
  • gi|224532|prf||1107278A erythroid potentiating activity [NCBI NR]
  • gi|189382|gb|AAA63234.1| collagenase inhibitor [Homo sapiens] [NCBI NR]
  • gi|189065155|dbj|BAG34878.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|182483|gb|AAA52436.1| prefibroblast collagenase inhibitor [Homo sapiens] [NCBI NR]
  • gi|135850|sp|P01033.1|TIMP1_HUMAN RecName: Full=Metalloproteinase inhibitor 1; AltName: Full=Tissue inhibitor of metalloproteinases; AltName: Full=TIMP-1; AltName: Full=Erythroid-potentiating activity; Short=EPA; AltName: Full=Fibroblast collagenase inhib [NCBI NR]
  • gi|12654107|gb|AAH00866.1| TIMP metallopeptidase inhibitor 1 [Homo sapiens] [NCBI NR]
  • gi|119579719|gb|EAW59315.1| TIMP metallopeptidase inhibitor 1, isoform CRA_a [Homo sapiens] [NCBI NR]
  • TIMP metallopeptidase inhibitor 1 [HGNC (HUGO)]
  • Metalloproteinase inhibitor 1 OS=Homo sapiens GN=TIMP1 PE=1 SV=1 [Swiss-Prot]
  • (P01033) Metalloproteinase inhibitor 1 precursor (TIMP-1) (Erythroid potentiating activity) (EPA) (Tissue inhibitor of metalloproteinases) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) [Swiss-Prot]
  • Metalloproteinase inhibitor 1 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases); erythroid potentiating activity [HMR_022704.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor; erythroid potentiating activity; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases) [Human2242005.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor [Homo sapiens]gi|12654107|gb|AAH00866.1| Tissue inhibitor of metalloproteinase 1, precursor [Homo sapiens]gi|189382|gb|AAA63234.1| collagenase inhibitor [Homo sapiens]gi|4261709|gb|AAD14009.1| metallopr [nrdb_11152004_Chlamydomonas]
  • Metalloproteinase inhibitor 1 precursor (TIMP-1) (Erythroid potentiating activity) (EPA) (Tissue inhibitor of metalloproteinases) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Metalloproteinase inhibitor 1 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003254) tissue inhibitor of metalloproteinase 1 precursor; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases); erythroid potentiating activity [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor; erythroid potentiating activity; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases) [Homo sapiens] [HumanGallus06162005.fasta]
  • tissue inhibitor of metalloproteinase 1 precursor; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases); erythroid potentiating activity [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Metalloproteinase inhibitor 1 precursor (Tissue inhibitor of metalloproteinases) (TIMP-1) (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • TIMP metallopeptidase inhibitor 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • TIMP metallopeptidase inhibitor 1, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • metalloproteinase inhibitor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • TIMP1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • collagenase inhibitor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • metalloproteinase inhibitor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • erythroid potentiating activity [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • TIMP [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • prefibroblast collagenase inhibitor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 METALLOPROTEINASE INHIBITOR 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TIMP1 Metalloproteinase inhibitor 1 [human-ipi-250309-contam.fasta]
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00032292.1|SWISS-PROT:P01033|TREMBL:B3KQF4;Q58P21;Q6FGX5|ENSEMBL:ENSP00000218388|REFSEQ:NP_003245|H-INV:HIT000029962|VEGA:OTTHUMP00000023214 Tax_Id=9606 Gene_Symbol=TIMP1 Metalloproteinase inhibitor 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=TIMP1 Metalloproteinase inhibitor 1 precursor ENSG00000102265 IPI00032292 IPI00639839 IPI00642739 IPI00552089 IPI00552339 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TIMP1 Metalloproteinase inhibitor 1 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • metalloproteinase inhibitor 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P01033;Q14252;Q9UCU1; RecName: Full=Metalloproteinase inhibitor 1; AltName: Full=Tissue inhibitor of metalloproteinases 1; AltName: Full=Erythroid-potentiating activity; AltName: Full=Fibroblast collagenase inhibitor; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Metalloproteinase inhibitor 1 OS=Homo sapiens GN=TIMP1 [011711_HMR.fasta]
  • TIMP metallopeptidase inhibitor 1 OS=Homo sapiens GN=TIMP1 [011711_HMR.fasta]
  • GeneSymbol=TIMP1 Synonyms=CLGI|EPA|EPO|FLJ90373|HCI|TIMP metalloproteinase inhibitor 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Metalloproteinase inhibitor 1 GN=TIMP1 [Doctor+uniprot-HUMAN-120911.fasta]
  • TIMP metallopeptidase inhibitor 1, isoform CRA_a OS=Homo sapiens GN=TIMP1 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 207 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP EVNQTTLYQR  60
   61 YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH NRSEEFLIAG KLQDGLLHIT 120
  121 TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK 180
  181 GFQSRHLACL PREPGLCTWQ SLRSQIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..207] PSI-BLAST 78.0 TIMP-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • metalloendopeptidase inhibitor activity
    		•  7.17434748400899 bayes_pls_golite062009
  • metalloenzyme regulator activity
    		•  7.17434748400899 bayes_pls_golite062009
  • metalloenzyme inhibitor activity
    		•  7.17434748400899 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  3.93668549411033 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  3.90361447859652 bayes_pls_golite062009
  • receptor binding
    		•  1.79096938850925 bayes_pls_golite062009
  • protein binding
    		•  1.78630177339498 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.54714635439345 bayes_pls_golite062009
  • binding
    		•  1.31216249528051 bayes_pls_golite062009
  • cytokine activity
    		•  1.02252345748708 bayes_pls_golite062009
  • chemokine activity
    		•  0.59253057522745 bayes_pls_golite062009
  • chemokine receptor binding
    		•  0.59253057522745 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.0664286291223601 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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