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Protein Overview: PSMD6

General Information:
Name(s) found: PSMD6 [HGNC (HUGO)]
Description(s) found:
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  • gi|7661914|ref|NP_055629.1| proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI NR]
  • gi|7643909|gb|AAF65540.1|AF215935_1 proteasome regulatory particle subunit p44S10 [Homo sapiens] [NCBI NR]
  • gi|45593848|gb|AAS68366.1| breast cancer associated protein SGA-113M [Homo sapiens] [NCBI NR]
  • gi|33329091|gb|AAQ09946.1| phosphonoformate immuno-associated protein 4 [Homo sapiens] [NCBI NR]
  • gi|285951|dbj|BAA03497.1| KIAA0107 [Homo sapiens] [NCBI NR]
  • gi|2494625|sp|Q15008.1|PSMD6_HUMAN RecName: Full=26S proteasome non-ATPase regulatory subunit 6; AltName: Full=26S proteasome regulatory subunit S10; AltName: Full=p42A; AltName: Full=Proteasome regulatory particle subunit p44S10; AltName: Full=Phosphonof [NCBI NR]
  • gi|158261433|dbj|BAF82894.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|15341749|gb|AAH12369.1| Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI NR]
  • gi|12654173|gb|AAH00904.1| Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI NR]
  • gi|12653691|gb|AAH00630.1| Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI NR]
  • gi|119585828|gb|EAW65424.1| proteasome (prosome, macropain) 26S subunit, non-ATPase, 6, isoform CRA_a [Homo sapiens] [NCBI NR]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [HGNC (HUGO)]
  • 26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens GN=PSMD6 PE=1 SV=1 [Swiss-Prot]
  • (Q15008) 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer-associated protein SGA-113M) [Swiss-Prot]
  • 26S proteasome non-ATPase regulatory subunit 6 [hmr_yeast5_DM3-1_pombe.fasta]
  • proteasome regulatory particle subunit p44S10 [HMR_022704.fasta]
  • proteasome regulatory particle subunit p44S10 [Homo sapiens]gi|33329091|gb|AAQ09946.1| phosphonoformate immuno-associated protein 4 [Homo sapiens]gi|12653691|gb|AAH00630.1| Proteasome regulatory particle subunit p44S10 [Homo sapiens]gi|12654173|gb|AAH0 [nrdb_11152004_Chlamydomonas]
  • 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer associated protein SGA-113M) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 26S proteasome non-ATPase regulatory subunit 6 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_014814) KIAA0107 gene product [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • proteasome regulatory particle subunit p44S10 [Homo sapiens] [HumanGallus06162005.fasta]
  • 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit S10) (p42A) (Proteasome regulatory particle subunit p44S10) (Phosphonoformate immuno-associated protein 4) (Breast cancer-associated protein SGA-113M) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 6, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • KIAA0107 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • breast cancer associated protein SGA-113M [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phosphonoformate immuno-associated protein 4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PSMD6 26S proteasome non-ATPase regulatory subunit 6 [human-ipi-250309-contam.fasta]
  • IPI:IPI00014151.3|SWISS-PROT:Q15008|TREMBL:A8K2E0|ENSEMBL:ENSP00000295901|REFSEQ:NP_055629|H-INV:HIT000074129|VEGA:OTTHUMP00000171748 Tax_Id=9606 Gene_Symbol=PSMD6 26S proteasome non-ATPase regulatory subunit 6 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PSMD6 26S proteasome non-ATPase regulatory subunit 6 ENSG00000163636 IPI00014151 IPI00797910 IPI00797167 IPI00794383 IPI00793676 IPI00795037 IPI00794344 IPI00792053 IPI00793381 [drosphohumanreversed.fasta]
  • 26S proteasome non-ATPase regulatory subunit 6 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q15008;A8K2E0; RecName: Full=26S proteasome non-ATPase regulatory subunit 6; AltName: Full=26S proteasome regulatory subunit S10; AltName: Full=p42A; AltName: Full=Proteasome regulatory particle subunit p44S10; AltName: Full=Phosphonoformate immuno-associated protein 4; AltName: Full=Breast cancer-associated protein SGA-113M; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • 26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens GN=PSMD6 [011711_HMR.fasta]
  • IPI:IPI00014151.3|SWISS-PROT:Q15008|ENSEMBL:ENSP00000295901|REFSEQ:NP_055629|H-INV:HIT000074129|VEGA:OTTHUMP00000171748 Tax_Id=9606 Gene_Symbol=PSMD6 26S proteasome non-ATPase regulatory subunit 6 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PSMD6 Synonyms=KIAA0107|Rpn7|S10|SGA-113M|p44S10 26S proteasome non-ATPase regulatory subunit 6 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00014151.3|SWISS-PROT:Q15008|ENSEMBL:ENSP00000295901|REFSEQ:NP_055629|H-INV:HIT000074129|VEGA:OTTHUMP00000213406 Tax_Id=9606 Gene_Symbol=PSMD6 26S proteasome non-ATPase regulatory subunit 6 [ipi.HUMAN.20110912.fasta]
  • 26S proteasome non-ATPase regulatory subunit 6 GN=PSMD6 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS  60
   61 LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA 120
  121 LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL 180
  181 KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV 240
  241 IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR 300
  301 IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD 360
  361 SKNWQYQETI KKGDLLLNRV QKLSRVINM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] FFAS03 2.47 No description for 2ifuA was found.
    2 View Details [285..389] PSI-BLAST 11.154902 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.50995556050336 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.38144578566524 bayes_pls_golite062009
  • binding
    		•  3.33026160538031 bayes_pls_golite062009
  • DNA binding
    		•  3.30822066787723 bayes_pls_golite062009
  • transcription factor activity
    		•  2.60537570879007 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30467124306022 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.32971938164691 bayes_pls_golite062009
  • transcription activator activity
    		•  1.08566311616647 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.95491822926452 bayes_pls_golite062009
  • protein binding
    		•  0.653872239015235 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.505349137311395 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42135864069093 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle