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Protein Overview: OPHN1

General Information:
Name(s) found: OPHN1 [HGNC (HUGO)]
Description(s) found:
Found 34 descriptions.
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  • oligophrenin 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 802 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHPPLEFSD CYLDSPDFRE RLKCYEQELE RTNKFIKDVI KDGNALISAM RNYSSAVQKF  60
   61 SQTLQSFQFD FIGDTLTDDE INIAESFKEF AELLNEVENE RMMMVHNASD LLIKPLENFR 120
  121 KEQIGFTKER KKKFEKDGER FYSLLDRHLH LSSKKKESQL QEADLQVDKE RHNFFESSLD 180
  181 YVYQIQEVQE SKKFNIVEPV LAFLHSLFIS NSLTVELTQD FLPYKQQLQL SLQNTRNHFS 240
  241 STREEMEELK KRMKEAPQTC KLPGQPTIEG YLYTQEKWAL GISWVKYYCQ YEKETKTLTM 300
  301 TPMEQKPGAK QGPLDLTLKY CVRRKTESID KRFCFDIETN ERPGTITLQA LSEANRRLWM 360
  361 EAMDGKEPIY HSPITKQQEM ELNEVGFKFV RKCINIIETK GIKTEGLYRT VGSNIQVQKL 420
  421 LNAFFDPKCP GDVDFHNSDW DIKTITSSLK FYLRNLSEPV MTYRLHKELV SAAKSDNLDY 480
  481 RLGAIHSLVY KLPEKNREML ELLIRHLVNV CEHSKENLMT PSNMGVIFGP TLMRAQEDTV 540
  541 AAMMNIKFQN IVVEILIEHF GKIYLGPPEE SAAPPVPPPR VTARRHKPIT ISKRLLRERT 600
  601 VFYTSSLDES EDEIQHQTPN GTITSSIEPP KPPQHPKLPI QRSGETDPGR KSPSRPILDG 660
  661 KLEPCPEVDV GKLVSRLQDG GTKITPKATN GPMPGSGPTK TPSFHIKRPA PRPLAHHKEG 720
  721 DADSFSKVRP PGEKPTIIRP PVRPPDPPCR AATPQKPEPK PDIVAGNAGE ITSSVVASRT 780
  781 RFFETASRKT GSSQGRLPGD ES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..361] PSI-BLAST 55.221849 No description for 2elbA was found.
    2 View Details [362..576] PSI-BLAST 47.0 Graf
    3 View Details [577..802] PSI-BLAST 3.69897 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  4.76659069034376 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • actin filament binding
    		•  2.99963220150463 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • profilin binding
    		•  0.91195854193678 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • transporter activity
    		•  0.882299675921716 bayes_pls_golite062009
  • receptor binding
    		•  0.50127063593663 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • receptor activity
    		•  0.353510125274044 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.276130226777911 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.2237168095091 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.207829786337892 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.118897432176337 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009
    2
    Term Confidence Notes
  • actin binding
    		•  4.17357159737697 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.42802398019084 bayes_pls_golite062009
  • GTPase regulator activity
    		•  3.22858435052736 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.20644605106099 bayes_pls_golite062009
  • GTPase activator activity
    		•  3.18597454327808 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.96155001519594 bayes_pls_golite062009
  • enzyme activator activity
    		•  2.92839426561878 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.87900480746065 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.8055856880102 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  2.79506512079992 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  2.58359112320183 bayes_pls_golite062009
  • actin filament binding
    		•  2.45667344398622 bayes_pls_golite062009
  • binding
    		•  2.26769740280417 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.74529419104576 bayes_pls_golite062009
  • motor activity
    		•  1.7327021907162 bayes_pls_golite062009
  • tubulin binding
    		•  1.56332747753627 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42814294153578 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42814294153578 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  1.35032386782255 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • microtubule binding
    		•  0.648232426961013 bayes_pls_golite062009
  • ADP binding
    		•  0.56346827542888 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.534597007915358 bayes_pls_golite062009
  • receptor activity
    		•  0.434186339265983 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.400842733744238 bayes_pls_golite062009
  • Rho GTPase binding
    		•  0.33949271618205 bayes_pls_golite062009
  • DNA binding
    		•  0.313042678225127 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle