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Protein Overview: EDF1

General Information:
Name(s) found: EDF1 [HGNC (HUGO)]
Description(s) found:
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  • gi|6526355|dbj|BAA88073.1| hMBF1alpha [Homo sapiens] [NCBI NR]
  • gi|62510569|sp|O60869.1|EDF1_HUMAN RecName: Full=Endothelial differentiation-related factor 1; Short=EDF-1; AltName: Full=Multiprotein-bridging factor 1; Short=MBF1 [NCBI NR]
  • gi|55958758|emb|CAI12697.1| endothelial differentiation-related factor 1 [Homo sapiens] [NCBI NR]
  • gi|49456783|emb|CAG46712.1| EDF1 [Homo sapiens] [NCBI NR]
  • gi|4503453|ref|NP_003783.1| endothelial differentiation-related factor 1 isoform alpha [Homo sapiens] [NCBI NR]
  • gi|32880069|gb|AAP88865.1| endothelial differentiation-related factor 1 [Homo sapiens] [NCBI NR]
  • gi|3043445|emb|CAA06446.1| EDF-1 [Homo sapiens] [NCBI NR]
  • gi|15930118|gb|AAH15500.1| Endothelial differentiation-related factor 1 [Homo sapiens] [NCBI NR]
  • endothelial differentiation-related factor 1 [HGNC (HUGO)]
  • Endothelial differentiation-related factor 1 OS=Homo sapiens GN=EDF1 PE=1 SV=1 [Swiss-Prot]
  • EDF-1 protein [hmr_yeast5_DM3-1_pombe.fasta]
  • endothelial differentiation-related factor 1 isoform alpha; multiprotein bridging factor 1 [HMR_022704.fasta]
  • endothelial differentiation-related factor 1 isoform alpha [Homo sapiens]gi|32880069|gb|AAP88865.1| endothelial differentiation-related factor 1 [Homo sapiens]gi|15930118|gb|AAH15500.1| Endothelial differentiation-related factor 1, isoform alpha [Homo s [nrdb_11152004_Chlamydomonas]
  • Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein bridging factor 1) (MBF1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Endothelial differentiation-related factor 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003792) endothelial differentiation-related factor 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • endothelial differentiation-related factor 1 isoform alpha [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 EDF-1 protein [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • endothelial differentiation-related factor 1 isoform alpha; multiprotein bridging factor 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • endothelial differentiation-related factor 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Endothelial differentiation-related factor 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • EDF1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • EDF-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hMBF1alpha [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Endothelial differentiation-related factor 1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 EDF-1 PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=EDF1 Isoform 1 of Endothelial differentiation-related factor 1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00021570.1|SWISS-PROT:O60869-1|ENSEMBL:ENSP00000224073|REFSEQ:NP_003783|H-INV:HIT000037144|VEGA:OTTHUMP00000022616 Tax_Id=9606 Gene_Symbol=EDF1 Isoform 1 of Endothelial differentiation-related factor 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=EDF1 Isoform 1 of Endothelial differentiation-related factor 1 ENSG00000107223 IPI00021570 IPI00006362 IPI00640567 [drosphohumanreversed.fasta]
  • O60869;Q5T5T2;Q9UIM1; RecName: Full=Endothelial differentiation-related factor 1; AltName: Full=Multiprotein-bridging factor 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Endothelial differentiation-related factor 1 OS=Homo sapiens GN=EDF1 [011711_HMR.fasta]
  • GeneSymbol=EDF1 Synonyms=EDF-1|MBF1|MGC9058 endothelial differentiation-related factor 1 isoform alpha [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Endothelial differentiation-related factor 1 GN=EDF1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 148 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK  60
   61 LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN EKPQVIADYE SGRAIPNNQV 120
  121 LGKIERAIGL KLRGKDIGKP IEKGPRAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] Pfam 33.221849 No description for PF08523.1 was found. No confident structure predictions are available.
    2 View Details [65..148] PSI-BLAST 10.522879 Solution structures of the HTH domain of human EDF-1 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • hydrolase activity
    		•  0.705005414525139 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle