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Protein Overview: lz-PB

General Information:
Name(s) found: lz-PB / FBpp0111726 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene lozenge is referred to in FlyBase by the symbol Dmel\lz (CG1689, FBgn0002576). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9178682..9197670. It has the cytological map location 8D5-8D6. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; hemocyte differentiation; hemopoietic or lymphoid organ development; wound healing; response to stress; sensory organ development; hemopoiesis; response to external stimulus; organ morphogenesis; regulation of biological process. 158 alleles are reported. The phenotypes of these alleles are annotated with 54 unique terms, many of which group under: adult segment; peripheral nervous system; external compound sense organ; antennal segment; nervous system; multi-cell-component structure; unguis; hemocyte; mouthpart; adult brain; appendage segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 705 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][ISS]
    Biological Process: embryonic crystal cell differentiation [IEP][IMP][TAS]
    larval lymph gland hemocyte differentiation [TAS]
    embryonic hemopoiesis [IMP]
    hemopoiesis [TAS]
    embryonic hemocyte differentiation [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IMP][TAS]
    regulation of transcription [IEA]
    compound eye cone cell differentiation [IMP]
    negative regulation of transcription from RNA polymerase II promoter [TAS]
    wound healing [IMP]
    cell fate determination [NAS]
    scab formation [IMP]
    spermathecum morphogenesis [TAS]
    signal transduction [NAS]
    regulation of transcription, DNA-dependent [IEA]
    lymph gland crystal cell differentiation [TAS]
    regulation of apoptosis [IMP]
    antennal development [TAS]
    defense response [NAS]
    compound eye development [TAS]
    crystal cell differentiation [IMP][NAS][TAS]
    eye morphogenesis [IMP]
    oogenesis [TAS]
    sensory organ precursor cell fate determination [TAS]
    cell fate commitment [TAS]
    positive regulation of compound eye retinal cell programmed cell death [IMP]
    cell differentiation [TAS]
    Molecular Function: ATP binding [IEA]
    DNA binding [IDA]
    transcription factor activity [IEA][NAS]
    RNA polymerase II transcription factor activity [IGI][ISS]
    RNA polymerase II transcription factor activity, enhancer binding [NAS]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLHLLAAEK TPPSPSPNPT PTPSASPSGH TGAAGESQLD LASQTESQLQ LGLPLASGYG  60
   61 LGLGLGLGLG LGLGQELVAD HSTTVAPVSV AGPGRLGRSI NGSGGSHHHH HLHHHYSPYH 120
  121 HAHPYHPPHP HAPHHHHHHH PPYPYPPAGP HPPAMVTSSS TSPTGNGWSS STGDFKGITA 180
  181 VATATGGGVG GATQGATAST GATAAEVLAV SSSASVGSSS PTGGASNGTA HSGHSGHTGG 240
  241 HSSSTASNNN NNGASNSNSN NNNAVHQDLL WMERLVQKRQ QEHPGELVRT SNPYFLCSAL 300
  301 PAHWRSNKTL PMAFKVVALA EVGDGTYVTI RAGNDENCCA ELRNFTTQMK NDVAKFNDLR 360
  361 FVGRSGRGKS FTLTITVATS PPQVATYAKA IKVTVDGPRE PRSKTTAEMM GAGEWTNGSS 420
  421 SSAAAYYHSH AHHPHAHHAH AHLQHQMALP PPPPPPAAAP VSVGVGGNGA TMGMGMGVGV 480
  481 GMGMNHYGGG YDSANSLEAG QYAAHLPAVL PEMHGHGFAT DPYQTAGYGG GNTGGGSASK 540
  541 SELDYGGSYN QAWSNGYQNY QYGSCLATAQ YGPQAAPPPQ PPPPPPVVLC PQLYSTVNQN 600
  601 QIHLHLHSSE KLEQYLGTAT SADHLTIGSL TGSSRSSIEI GQDQYHQQVH HAQQQQQQQQ 660
  661 QQQQVHHPQQ QQVESAGEVG GSGAGGVESA REEDVGDLSQ VWRPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle