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Protein Overview: SMN2, SMN1

General Information:
Name(s) found: SMN2 [HGNC (HUGO)]
SMN1 [HGNC (HUGO)]
Description(s) found:
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  • gi|624186|gb|AAA66242.1| survival motor neuron [NCBI NR]
  • gi|4507091|ref|NP_000335.1| survival of motor neuron 1, telomeric isoform d [Homo sapiens] [NCBI NR]
  • gi|3970964|gb|AAC83178.1| survival motor neuron 1 protein [Homo sapiens] [NCBI NR]
  • gi|38571800|gb|AAH62723.1| Survival of motor neuron 1, telomeric [Homo sapiens] [NCBI NR]
  • gi|3688111|gb|AAC62262.1| survival of motor neuron 1 product [Homo sapiens] [NCBI NR]
  • gi|2498924|sp|Q16637.1|SMN_HUMAN RecName: Full=Survival motor neuron protein; AltName: Full=Component of gems 1; AltName: Full=Gemin-1 [NCBI NR]
  • gi|1737214|gb|AAC52048.1| survival motor neuron protein SMN [Homo sapiens] [NCBI NR]
  • gi|169167328|ref|XP_001713660.1| PREDICTED: hypothetical protein isoform 1 [Homo sapiens] [NCBI NR]
  • gi|169167320|ref|XP_001713766.1| PREDICTED: hypothetical protein isoform 1 [Homo sapiens] [NCBI NR]
  • gi|15929774|gb|AAH15308.1| Survival of motor neuron 2, centromeric [Homo sapiens] [NCBI NR]
  • gi|1314346|gb|AAC50473.1| survival motor neuron [Homo sapiens] [NCBI NR]
  • gi|10937869|ref|NP_059107.1| survival of motor neuron 2, centromeric isoform d [Homo sapiens] [NCBI NR]
  • pir||A55477 survival motor neuron protein - human [NCBI NR]
  • survival of motor neuron 2, centromeric [HGNC (HUGO)]
  • survival of motor neuron 1, telomeric [HGNC (HUGO)]
  • Survival motor neuron protein OS=Homo sapiens GN=SMN1 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform SMN of Q16637 [hmr_yeast5_DM3-1_pombe.fasta]
  • survival of motor neuron 1, telomeric isoform d; gemin 1 [HMR_022704.fasta]
  • survival of motor neuron 2, centromeric isoform d; gemin 1 [HMR_022704.fasta]
  • survival of motor neuron 2, centromeric isoform d [Homo sapiens]gi|4507091|ref|NP_000335.1| survival of motor neuron 1, telomeric isoform d [Homo sapiens]gi|38571800|gb|AAH62723.1| Survival of motor neuron 1, telomeric, isoform d [Homo sapiens]gi|15929 [nrdb_11152004_Chlamydomonas]
  • Survival motor neuron protein (Component of gems 1) (Gemin1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform SMN of Survival motor neuron protein [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000344) survival of motor neuron 1, telomeric isoform d; gemin 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • (NM_017411) survival of motor neuron 2, centromeric isoform d; gemin 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • survival of motor neuron 1, telomeric isoform d [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • survival of motor neuron 2, centromeric isoform d [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • survival of motor neuron 2, centromeric isoform d; gemin 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • survival of motor neuron 1, telomeric isoform d; gemin 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • Survival of motor neuron 2, centromeric [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Survival motor neuron protein (Component of gems 1) (Gemin-1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • PREDICTED: hypothetical protein isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Survival of motor neuron 1, telomeric [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • survival motor neuron [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • survival motor neuron protein SMN [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • survival motor neuron 1 protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • survival of motor neuron 1 product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • survival motor neuron [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform SMN of Survival motor neuron protein [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF SURVIVAL MOTOR NEURON PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Survival motor neuron protein; AltName: Full=Component of gems 1; AltName: Full=Gemin-1 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SMN2;SMN1 Isoform SMN of Survival motor neuron protein [human-ipi-250309-contam.fasta]
  • IPI:IPI00003394.1|SWISS-PROT:Q16637-1|ENSEMBL:ENSP00000370083;ENSP00000370119;ENSP00000412162|REFSEQ:NP_000335;NP_059107|H-INV:HIT000218455|VEGA:OTTHUMP00000125198;OTTHUMP00000125236 Tax_Id=9606 Gene_Symbol=SMN1;SMN2 Isoform SMN of Survival motor neuron p [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SMN2;SMN1 Isoform SMN of Survival motor neuron protein ENSG00000172062 IPI00219360 IPI00003394 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SMN1;SMN2 Isoform SMN of Survival motor neuron protein [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • survival motor neuron protein isoform d [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q16637;A8K0V4;Q13119;Q549U5;Q96J51; RecName: Full=Survival motor neuron protein; AltName: Full=Component of gems 1; AltName: Full=Gemin-1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform SMN of Survival motor neuron protein OS=Homo sapiens GN=SMN1 [011711_HMR.fasta]
  • IPI:IPI00003394.1|SWISS-PROT:Q16637-1|ENSEMBL:ENSP00000370083;ENSP00000370119;ENSP00000412162|REFSEQ:NP_000335;NP_059107|H-INV:HIT000218455|VEGA:OTTHUMP00000125198;OTTHUMP00000125236 Tax_Id=9606 Gene_Symbol=SMN1;SMN2 Isoform SMN of Survival motor neuron protein [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=SMN2 Synonyms=BCD541|C-BCD541|FLJ76644|MGC20996|MGC5208|SMN1|SMNC survival motor neuron protein isoform d [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • GeneSymbol=SMN1 Synonyms=BCD541|SMA|SMA1|SMA2|SMA3|SMA4|SMA@|SMN|SMN2|SMNT|T-BCD541 survival motor neuron protein isoform d [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00003394.1|SWISS-PROT:Q16637-1|ENSEMBL:ENSP00000370083;ENSP00000370119;ENSP00000437834|REFSEQ:NP_000335;NP_059107|H-INV:HIT000218455|VEGA:OTTHUMP00000125198;OTTHUMP00000125236 Tax_Id=9606 Gene_Symbol=SMN1;SMN2 Isoform SMN of Survival motor neuron protein [ipi.HUMAN.20110912.fasta]
  • Survival motor neuron protein GN=SMN1 [Doctor+uniprot-HUMAN-120911.fasta]
  • IPI:IPI00003394.1|SWISS-PROT:Q16637-1|TREMBL:F5H6Q6|ENSEMBL:ENSP00000370083;ENSP00000370119|REFSEQ:NP_000335;NP_059107|H-INV:HIT000218455|VEGA:OTTHUMP00000125198;OTTHUMP00000125236 Tax_Id=9606 Gene_Symbol=SMN2;SMN1 Isoform SMN of Survival motor neuron protein [ipi.HUMAN.fasta.20110927]
    • Organism: Homo sapiens
    Length: 294 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC  60
   61 ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR 120
  121 ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS 180
  181 DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP 240
  241 PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] MSA 1.135974 View MSA. No confident structure predictions are available.
    2 View Details [73..166] PSI-BLAST 28.30103 Survival motor neuron protein 1, smn
    3 View Details [167..294] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.8914433770482 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23645140702533 bayes_pls_golite062009
  • protein binding
    		•  1.97653343528228 bayes_pls_golite062009
  • DNA binding
    		•  1.38254179968032 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29663886491206 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.85415557686977 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.81676066297927 bayes_pls_golite062009
  • transcription factor binding
    		•  0.77325691466894 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567394926956068 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.53946303154276 bayes_pls_golite062009
  • chromatin binding
    		•  0.25107231011304 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.223495463070134 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.21258120552184 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0304922925916231 bayes_pls_golite062009
  • histone binding
    		•  0.0149490634137095 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle