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Protein Overview: CE40394

General Information:
Name(s) found: CE40394 [WormBase]
Description(s) found:
Found 12 descriptions.
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  • WBGene00010912 locus:gmps-1 Probable GMP synthase [glutamine-hydrolyzing] status:Confirmed UniProt:Q09580 protein_id:CAL36508.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 709 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: purine nucleotide biosynthetic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    'de novo' IMP biosynthetic process [IEALink to PubMed article]
    GMP biosynthetic process [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    GMP synthase (glutamine-hydrolyzing) activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    anthranilate synthase activity [IEALink to PubMed article]
    phosphoribosylformylglycinamidine synthase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNASGSHVTL VENLPVEKVS SGERIAILDF GAQYGKVIDR RVRELLVQSE MFPLNTTART  60
   61 LIELGGFKGI IISGGPNSVF EPEAPSIDPE IFTCGLPVLG ICYGFQLMNK LNGGTVTREH 120
  121 IREDGACEIQ VDTSVHLFNG LHKTETVLLT HGDSVSEATV APDFKVMAKS GHHVAGICNE 180
  181 NRKLYGVQFH PEVDLTTNGT KMFENFLFKV VGCCGNFTIQ NREQSCISEI NSIVGDKKVL 240
  241 VMVSGGVDSA VCAALLRRAL GPNRVTAIHI DNGFMRHEES DAVEKSLAAL DLPIHRYNFG 300
  301 TTFRSSTEHC KDGEVALDEC DDPEMKRKII GNTFIRVKDV IMKDLNINHD EYFLAQGTLR 360
  361 PDLIESASAL ASGHADTIKT HHNDTFLVRE LRKLGKVVEP LKDFHKDEVR ELGKDLGLPE 420
  421 SIVQRHPFPG PGLAIRILCA SDKRPELMFN GPMYNGDVQG RIIDVTEQFL NSAINPSQGI 480
  481 YEHLQFEQAR NNVLLSLSER DRQLAEQQTF QISAHILPIK TVGVQGDARS YSYAVALSTE 540
  541 QRPIPWKLLF AYASVIPKLF HGVNRVVYAF GSKIEFSIED LTRTYLVPHI VTKLQMADHI 600
  601 ANNILFGRVA ASDGTQLPNV GHKIQQMPVV LLPVDFDRDR DMIGSYRHSI VLRPFVTSDF 660
  661 MTGQAAIPGV HLPEETLIEM DKAIRTNVLG ISRVLLDMTC KPPGTTEWE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..579] PSI-BLAST 136.0 GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
    2 View Details [580..709] FFAS03 6.12 GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.21758353153797 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  2.70451256281397 bayes_pls_golite062009
  • anthranilate synthase activity
    		•  2.51214170411838 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.83575136996743 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.74828881793189 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.74029540439985 bayes_pls_golite062009
  • ligase activity
    		•  1.70348758031146 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  1.63674478001979 bayes_pls_golite062009
  • oxo-acid-lyase activity
    		•  1.35896725827905 bayes_pls_golite062009
  • catalytic activity
    		•  1.30391542469987 bayes_pls_golite062009
  • binding
    		•  0.651391283589745 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58055486321736 bayes_pls_golite062009
  • kinase activity
    		•  0.557302038379807 bayes_pls_golite062009
  • transferase activity
    		•  0.540671801549001 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.471850306495912 bayes_pls_golite062009
  • GMP synthase activity
    		•  0.413068109408727 bayes_pls_golite062009
  • asparagine synthase (glutamine-hydrolyzing) activity
    		•  0.3673193848392 bayes_pls_golite062009
  • imidazoleglycerol-phosphate synthase activity
    		•  0.270391651600004 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.12569720972861 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.0769356405014503 bayes_pls_golite062009
  • protein binding
    		•  0.0381338084094011 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle