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Protein Overview: GTF2H1

General Information:
Name(s) found: GTF2H1 [HGNC (HUGO)]
Description(s) found:
Found 43 descriptions.
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  • general transcription factor IIH, polypeptide 1, 62kDa [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI KCQKISPEGK  60
   61 AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL PKFKRKANKE LEEKNRMLQE 120
  121 DPVLFQLYKD LVVSQVISAE EFWANRLNVN ATDSSSTSNH KQDVGISAAF LADVRPQTDG 180
  181 CNGLRYNLTS DIIESIFRTY PAVKMKYAEN VPHNMTEKEF WTRFFQSHYF HRDRLNTGSK 240
  241 DLFAECAKID EKGLKTMVSL GVKNPLLDLT ALEDKPLDEG YGISSVPSAS NSKSIKENSN 300
  301 AAIIKRFNHH SAMVLAAGLR KQEAQNEQTS EPSNMDGNSG DADCFQPAVK RAKLQESIEY 360
  361 EDLGKNNSVK TIALNLKKSD RYYHGPTPIQ SLQYATSQDI INSFQSIRQE MEAYTPKLTQ 420
  421 VLSSSAASST ITALSPGGAL MQGGTQQAIN QMVPNDIQSE LKHLYVAVGE LLRHFWSCFP 480
  481 VNTPFLEEKV VKMKSNLERF QVTKLCPFQE KIRRQYLSTN LVSHIEEMLQ TAYNKLHTWQ 540
  541 SRRLMKKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 46.0 Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
    2 View Details [109..298] Pfam 18.008774 No description for PF03909.8 was found. No confident structure predictions are available.
    3 View Details [299..435] MSA 1.036979 View MSA. No confident structure predictions are available.
    4 View Details [436..548] MSA 2.03499 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.19860786133833 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10584700564436 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.05456820914801 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85794418941003 bayes_pls_golite062009
  • DNA binding
    		•  1.77960272183811 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.38051627844132 bayes_pls_golite062009
  • enzyme binding
    		•  0.977337620102034 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.704949129344961 bayes_pls_golite062009
  • protein kinase activity
    		•  0.565124275151513 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.361321073558889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.354215977182915 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.268141992393579 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.242734483980252 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.236765394237244 bayes_pls_golite062009
  • kinase activity
    		•  0.206532566781865 bayes_pls_golite062009
  • kinase binding
    		•  0.144753921529348 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0735802149531289 bayes_pls_golite062009
  • actin binding
    		•  0.0485598963526399 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle