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Protein Overview: KLK2

General Information:
Name(s) found: KLK2 [HGNC (HUGO)]
Description(s) found:
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  • pir||A29586 tissue kallikrein (EC 3.4.21.35) hGK-1 precursor - human [NCBI NR]
  • gi|6425046|gb|AAF08276.1|AF188746_1 prostrate kallikrein 2 [Homo sapiens] [NCBI NR]
  • gi|5031829|ref|NP_005542.1| kallikrein 2, prostatic isoform 1 [Homo sapiens] [NCBI NR]
  • gi|4261522|gb|AAD13816.1|S39329_1 glandular kallikrein-1 [Homo sapiens] [NCBI NR]
  • gi|386842|gb|AAA74454.1| glandular kallikrein precursor [Homo sapiens] [NCBI NR]
  • gi|30582139|gb|AAP35296.1| kallikrein 2, prostatic [Homo sapiens] [NCBI NR]
  • gi|13528792|gb|AAH05196.1| Kallikrein-related peptidase 2 [Homo sapiens] [NCBI NR]
  • gi|125174|sp|P20151.1|KLK2_HUMAN RecName: Full=Kallikrein-2; AltName: Full=Tissue kallikrein-2; AltName: Full=Glandular kallikrein-1; Short=hGK-1; Flags: Precursor [NCBI NR]
  • gi|119592346|gb|EAW71940.1| kallikrein 2, prostatic, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119592343|gb|EAW71937.1| kallikrein 2, prostatic, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|11244761|gb|AAG33356.1|AF243527_4 glandular kallikrein [Homo sapiens] [NCBI NR]
  • kallikrein-related peptidase 2 [HGNC (HUGO)]
  • Kallikrein-2 OS=Homo sapiens GN=KLK2 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform 1 of P20151 [hmr_yeast5_DM3-1_pombe.fasta]
  • kallikrein 2, prostatic [HMR_022704.fasta]
  • kallikrein 2, prostatic isoform 1 [071204_hmrz_cont.fasta]
  • kallikrein 2, prostatic isoform 1 [Homo sapiens]gi|30582139|gb|AAP35296.1| kallikrein 2, prostatic [Homo sapiens]gi|13528792|gb|AAH05196.1| Kallikrein 2, prostatic [Homo sapiens]gi|6425046|gb|AAF08276.1| prostrate kallikrein 2 [Homo sapiens]gi|4261522 [nrdb_11152004_Chlamydomonas]
  • Kallikrein 2 precursor (Tissue kallikrein 2) (Glandular kallikrein-1) (hGK-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Kallikrein-2 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005551) kallikrein 2, prostatic [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • kallikrein 2, prostatic isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Kallikrein 2 precursor [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • kallikrein 2, prostatic [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Kallikrein-2 precursor (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • kallikrein 2, prostatic, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Kallikrein-related peptidase 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • glandular kallikrein-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • glandular kallikrein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • prostrate kallikrein 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • glandular kallikrein precursor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Kallikrein-2 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF KALLIKREIN 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=KLK2 Isoform 1 of Kallikrein-2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00022227.1|SWISS-PROT:P20151-1|TREMBL:B4DU77;B4DU93|ENSEMBL:ENSP00000313581|REFSEQ:NP_005542|H-INV:HIT000072985|VEGA:OTTHUMP00000077143 Tax_Id=9606 Gene_Symbol=KLK2 Isoform 1 of Kallikrein-2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=KLK2 Isoform 1 of Kallikrein-2 precursor ENSG00000167751 IPI00022227 IPI00447786 IPI00854682 IPI00434943 IPI00219231 IPI00383167 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=KLK2 Isoform 1 of Kallikrein-2 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • kallikrein-2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Kallikrein-2 OS=Homo sapiens GN=KLK2 PE=2 SV=1 [UniProtHuman070710.fasta]
  • P20151;Q15946;Q9UJZ9; RecName: Full=Kallikrein-2; AltName: Full=Tissue kallikrein-2; AltName: Full=Glandular kallikrein-1; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Kallikrein-2 OS=Homo sapiens GN=KLK2 [011711_HMR.fasta]
  • GeneSymbol=KLK2 Synonyms=KLK2A2|MGC12201|hK2 kallikrein-2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00022227.1|SWISS-PROT:P20151-1|TREMBL:B4DU77;B4DU93|ENSEMBL:ENSP00000313581|REFSEQ:NP_005542|H-INV:HIT000072985 Tax_Id=9606 Gene_Symbol=KLK2 Isoform 1 of Kallikrein-2 [ipi.HUMAN.20110912.fasta]
  • Kallikrein-2 GN=KLK2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Kallikrein 2, prostatic, isoform CRA_a OS=Homo sapiens GN=KLK2 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 261 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWDLVLSIAL SVGCTGAVPL IQSRIVGGWE CEKHSQPWQV AVYSHGWAHC GGVLVHPQWV  60
   61 LTAAHCLKKN SQVWLGRHNL FEPEDTGQRV PVSHSFPHPL YNMSLLKHQS LRPDEDSSHD 120
  121 LMLLRLSEPA KITDVVKVLG LPTQEPALGT TCYASGWGSI EPEEFLRPRS LQCVSLHLLS 180
  181 NDMCARAYSE KVTEFMLCAG LWTGGKDTCG GDSGGPLVCN GVLQGITSWG PEPCALPEKP 240
  241 AVYTKVVHYR KWIKDTIAAN P

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] PSI-BLAST 71.221849 7S NGF protease subunits

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.91209560688646 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  5.52773635813967 bayes_pls_golite062009
  • serine hydrolase activity
    		•  5.5105092190926 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  5.49703869306079 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  5.39623690248556 bayes_pls_golite062009
  • endopeptidase activity
    		•  5.32070018460528 bayes_pls_golite062009
  • hydrolase activity
    		•  4.40346950809697 bayes_pls_golite062009
  • fucose binding
    		•  3.5000591397073 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.01328116441763 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  1.96509840108953 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73928761064649 bayes_pls_golite062009
  • DNA binding
    		•  1.61536775064425 bayes_pls_golite062009
  • heparin binding
    		•  1.48285358055737 bayes_pls_golite062009
  • thrombospondin receptor activity
    		•  1.44312413043539 bayes_pls_golite062009
  • catalytic activity
    		•  1.40927913545237 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.34665327732001 bayes_pls_golite062009
  • binding
    		•  1.30738106455622 bayes_pls_golite062009
  • protein binding
    		•  1.30414885212044 bayes_pls_golite062009
  • receptor activity
    		•  1.10676631226741 bayes_pls_golite062009
  • serine-type aminopeptidase activity
    		•  0.964413112640311 bayes_pls_golite062009
  • signal transducer activity
    		•  0.885246794092463 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.885246794092463 bayes_pls_golite062009
  • growth factor activity
    		•  0.848900101748605 bayes_pls_golite062009
  • receptor binding
    		•  0.79054390509229 bayes_pls_golite062009
  • calcium ion binding
    		•  0.753095272942721 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  0.30724450617383 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle