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Protein Overview: DNAJC3

General Information:
Name(s) found: DNAJC3 [HGNC (HUGO)]
Description(s) found:
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  • gi|73620807|sp|Q13217.1|DNJC3_HUMAN RecName: Full=DnaJ homolog subfamily C member 3; AltName: Full=Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; AltName: Full=Protein kinase inhibitor of 58 kDa; AltName: Full=Protein kinase i [NCBI NR]
  • gi|55661851|emb|CAH70090.1| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI NR]
  • gi|54781373|gb|AAV40838.1| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI NR]
  • gi|5453980|ref|NP_006251.1| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI NR]
  • gi|37574015|gb|AAH47936.2| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI NR]
  • pir||JC4775 interferon-induced double-stranded RNA-activated protein kinase inhibitor - human [NCBI NR]
  • gi|189053547|dbj|BAG35713.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|158259355|dbj|BAF85636.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|1353270|gb|AAC50502.1| p58 [NCBI NR]
  • gi|119629364|gb|EAX08959.1| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI NR]
  • DnaJ (Hsp40) homolog, subfamily C, member 3 [HGNC (HUGO)]
  • DnaJ homolog subfamily C member 3 OS=Homo sapiens GN=DNAJC3 PE=1 SV=1 [Swiss-Prot]
  • P58 [hmr_yeast5_DM3-1_pombe.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor [HMR_022704.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]gi|5453980|ref|NP_006251.1| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]gi|37574015|gb|AAH47936.2| DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]gi|55661851|emb|CAH7009 [nrdb_11152004_Chlamydomonas]
  • DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of DnaJ homolog subfamily C member 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006260) protein-kinase, interferon-inducible double stranded RNA dependent inhibitor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 P58 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor [Homo sapiens] [HumanGallus06162005.fasta]
  • DnaJ homolog subfamily C member 3 precursor (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • p58 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of DnaJ homolog subfamily C member 3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=DNAJC3 Isoform 1 of DnaJ homolog subfamily C member 3 [human-ipi-250309-contam.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3 precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00006713.1|SWISS-PROT:Q13217-1|TREMBL:A8KA82|ENSEMBL:ENSP00000365991|REFSEQ:NP_006251|H-INV:HIT000098845|VEGA:OTTHUMP00000018567 Tax_Id=9606 Gene_Symbol=DNAJC3 Isoform 1 of DnaJ homolog subfamily C member 3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=DNAJC3 Isoform 1 of DnaJ homolog subfamily C member 3 ENSG00000102580 IPI00166730 IPI00006713 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=DNAJC3 DnaJ homolog subfamily C member 3 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • dnaJ homolog subfamily C member 3 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q13217;Q86WT9;Q8N4N2; RecName: Full=DnaJ homolog subfamily C member 3; AltName: Full=Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; AltName: Full=Protein kinase inhibitor of 58 kDa; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • DnaJ homolog subfamily C member 3 OS=Homo sapiens GN=DNAJC3 [011711_HMR.fasta]
  • IPI:IPI00006713.1|SWISS-PROT:Q13217|TREMBL:A8KA82|ENSEMBL:ENSP00000365991|REFSEQ:NP_006251|H-INV:HIT000098845|VEGA:OTTHUMP00000018567 Tax_Id=9606 Gene_Symbol=DNAJC3 DnaJ homolog subfamily C member 3 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=DNAJC3 Synonyms=FLJ21288|HP58|P58|P58IPK|PRKRI dnaJ homolog subfamily C member 3 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • DnaJ homolog subfamily C member 3 GN=DNAJC3 [Doctor+uniprot-HUMAN-120911.fasta]
  • DnaJ (Hsp40) homolog, subfamily C, member 3 OS=Homo sapiens GN=DNAJC3 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA GQLADALSQF  60
   61 HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL KMDFTAARLQ RGHLLLKQGK 120
  121 LDEAEDDFKK VLKSNPSENE EKEAQSQLIK SDEMQRLRSQ ALNAFGSGDY TAAIAFLDKI 180
  181 LEVCVWDAEL RELRAECFIK EGEPRKAISD LKAASKLKND NTEAFYKIST LYYQLGDHEL 240
  241 SLSEVRECLK LDQDHKRCFA HYKQVKKLNK LIESAEELIR DGRYTDATSK YESVMKTEPS 300
  301 IAEYTVRSKE RICHCFSKDE KPVEAIRVCS EVLQMEPDNV NALKDRAEAY LIEEMYDEAI 360
  361 QDYETAQEHN ENDQQIREGL EKAQRLLKQS QKRDYYKILG VKRNAKKQEI IKAYRKLALQ 420
  421 WHPDNFQNEE EKKKAEKKFI DIAAAKEVLS DPEMRKKFDD GEDPLDAESQ QGGGGNPFHR 480
  481 SWNSWQGFNP FSSGGPFRFK FHFN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..401] PSI-BLAST 41.69897 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [402..504] PSI-BLAST 8.045757 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.07985546140154 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.23450221149054 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.03065657981002 bayes_pls_golite062009
  • enzyme binding
    		•  0.44905827271946 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.389874293041007 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.35164886746762 bayes_pls_golite062009
  • DNA binding
    		•  0.244553192560639 bayes_pls_golite062009
    2
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.06176335248157 bayes_pls_golite062009
  • binding
    		•  1.99149924818543 bayes_pls_golite062009
  • protein binding
    		•  1.60937254813642 bayes_pls_golite062009
  • chaperone binding
    		•  1.57325829043476 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.472629059184113 bayes_pls_golite062009
  • kinase activity
    		•  0.466886050736282 bayes_pls_golite062009
  • protein kinase activity
    		•  0.36885370400914 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.358068043290742 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.341554040400357 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.32785918835419 bayes_pls_golite062009
  • DNA binding
    		•  0.170257507064939 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.132809854474755 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle