Protein Overview: TARDBP

General Information:
Name(s) found:	TARDBP [HGNC (HUGO)]
Description(s) found: Found 40 descriptions. SHOW ALL	TAR DNA binding protein [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	414 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI  60
   61 LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL 120
  121 KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS 180
  181 KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA 240
  241 QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG 300
  301 NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ 360
  361 REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..87]	PSI-BLAST	4.522879	No description for 2aymA was found.
2	View Details	[88..173]	PSI-BLAST	17.522879	Solution structure of the RNA binding domain of TAR DNA-binding protein-43
3	View Details	[174..265]	FFAS03	4.76	Solution structure of RRM domain in TAR DNA-binding protein-43
4	View Details	[266..414]	PSI-BLAST	4.522879	Sec24

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
nucleic acid binding	4.50398990564944	bayes_pls_golite062009
binding	4.16717332578111	bayes_pls_golite062009
RNA binding	2.92438188845619	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
mRNA binding	1.94495589345842	bayes_pls_golite062009
DNA binding	1.73925834998328	bayes_pls_golite062009
protein binding	1.32954276279597	bayes_pls_golite062009
transcription factor activity	0.873765500321315	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.632534695085793	bayes_pls_golite062009
sequence-specific DNA binding	0.294937517750882	bayes_pls_golite062009
	0.00244208777479016	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
nucleic acid binding	4.23531598582972	bayes_pls_golite062009
binding	4.00350364031155	bayes_pls_golite062009
RNA binding	2.51560202858525	bayes_pls_golite062009
transcription regulator activity	2.2045206027152	bayes_pls_golite062009
DNA binding	1.74537942253096	bayes_pls_golite062009
mRNA binding	1.52376515340629	bayes_pls_golite062009
protein binding	1.26544376923141	bayes_pls_golite062009
transcription factor activity	0.894914712180715	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.633093884585572	bayes_pls_golite062009
sequence-specific DNA binding	0.238420044364247	bayes_pls_golite062009

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.42

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle