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View Structure Prediction Details

Protein: TARDBP
Organism: Homo sapiens
Length: 414 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TARDBP.

Description E-value Query
Range		 Subject
Range
gi|13560783 - gi|13560783|gb|AAK30205.1|AF349964_1 poly(A)-binding protein [Daucus carota]
 1.0E-61 [12..413] [128..559]
gi|13430610 - gi|13430610|gb|AAK25927.1|AF360217_1 putative poly(A) binding protein [Arabidopsis thaliana]
 2.0E-61 [11..414] [133..548]
gi|73974148 - gi|73974148|ref|XP_857082.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
 7.0E-61 [7..410] [94..523]
gi|76689285 - gi|76689285|ref|XP_881509.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
 8.0E-60 [7..368] [94..474]

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Predicted Domain #1
Region A:
Residues: [1-87] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI  60
   61 LHAPDAGWGN LVYVVNYPKD NKRKMDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 2aymA
Description: No description for 2aymA was found.

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.50398990564944 bayes_pls_golite062009
binding 4.16717332578111 bayes_pls_golite062009
RNA binding 2.92438188845619 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
mRNA binding 1.94495589345842 bayes_pls_golite062009
DNA binding 1.73925834998328 bayes_pls_golite062009
protein binding 1.32954276279597 bayes_pls_golite062009
transcription factor activity 0.873765500321315 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.632534695085793 bayes_pls_golite062009
sequence-specific DNA binding 0.294937517750882 bayes_pls_golite062009
0.00244208777479016 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [88-173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDASSAVKVK RAVQKTSDLI VLGLPWKTTE QDLKEYFSTF GEVLMVQVKK DLKTGHSKGF  60
   61 GFVRFTEYET QVKVMSQRHM IDGRWC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 2cqgA
Description: Solution structure of the RNA binding domain of TAR DNA-binding protein-43
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [174-265] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCKLPNSKQS QDEPLRSRKV FVGRCTEDMT EDELREFFSQ YGDVMDVFIP KPFRAFAFVT  60
   61 FADDQIAQSL CGEDLIIKGI SVHISNAEPK HN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.76
Match: 1wf0A
Description: Solution structure of RRM domain in TAR DNA-binding protein-43
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.23531598582972 bayes_pls_golite062009
binding 4.00350364031155 bayes_pls_golite062009
RNA binding 2.51560202858525 bayes_pls_golite062009
transcription regulator activity 2.2045206027152 bayes_pls_golite062009
DNA binding 1.74537942253096 bayes_pls_golite062009
mRNA binding 1.52376515340629 bayes_pls_golite062009
protein binding 1.26544376923141 bayes_pls_golite062009
transcription factor activity 0.894914712180715 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.633093884585572 bayes_pls_golite062009
sequence-specific DNA binding 0.238420044364247 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [266-414] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNRQLERSGR FGGNPGGFGN QGGFGNSRGG GAGLGNNQGS NMGGGMNFGA FSINPAMMAA  60
   61 AQAALQSSWG MMGMLASQQN QSGPSGNNQN QGNMQREPNQ AFGSGNNSYS GSNSGAAIGW 120
  121 GSASNAGSGS GFNGGFGSSM DSKSSGWGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle