Protein Overview: SMUG1

General Information:
Name(s) found:	SMUG1 [HGNC (HUGO)]
Description(s) found: Found 36 descriptions. SHOW ALL	single-strand-selective monofunctional uracil-DNA glycosylase 1 [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	270 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY  60
   61 AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 120
  121 HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA 180
  181 ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP 240
  241 SPRNPQANKG WEAVAKERLN ELGLLPLLLK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..270]	PSI-BLAST	119.0	Single-strand selective monofunctional uracil-DNA glycosylase SMUG1

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
DNA N-glycosylase activity	5.22461096584694	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.68115068202636	bayes_pls_golite062009
uracil DNA N-glycosylase activity	4.48822773983461	bayes_pls_golite062009
single-strand selective uracil DNA N-glycosylase activity	3.83194769747125	bayes_pls_golite062009
hydrolase activity	2.80752243868997	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.59556365302624	bayes_pls_golite062009
structure-specific DNA binding	1.75635693402802	bayes_pls_golite062009
catalytic activity	1.59111295908728	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	1.34999321643757	bayes_pls_golite062009
binding	1.2276262882727	bayes_pls_golite062009
single-stranded DNA binding	1.14199628308287	bayes_pls_golite062009
nucleic acid binding	0.901890891144085	bayes_pls_golite062009
DNA binding	0.850361767185031	bayes_pls_golite062009
transcription regulator activity	0.543168797464517	bayes_pls_golite062009
damaged DNA binding	0.44704532195099	bayes_pls_golite062009
double-stranded DNA binding	0.307323249123648	bayes_pls_golite062009
protein binding	0.272261244770552	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.53

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle