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View Structure Prediction Details

Protein: SMUG1
Organism: Homo sapiens
Length: 270 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMUG1.

Description E-value Query
Range
Subject
Range
gi|55638177, gi|... - gi|55638177|ref|XP_509109.1| PREDICTED: single-strand selective monofunctional uracil DNA glycosylas...
0.0 [1..258] [1..258]
SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1
0.0 [1..258] [1..258]
gi|109097013, gi... - gi|109097019|ref|XP_001109359.1| PREDICTED: similar to single-strand selective monofunctional uracil...
0.0 [1..258] [1..258]
SMUG1_MOUSE - Single-strand selective monofunctional uracil DNA glycosylase OS=Mus musculus GN=Smug1 PE=1 SV=1
0.0 [3..258] [5..260]
SMUG1_RAT - Single-strand selective monofunctional uracil-DNA glycosylase OS=Rattus norvegicus GN=Smug1 PE=2 SV=...
0.0 [3..258] [5..258]
gi|73996356 - gi|73996356|ref|XP_543623.2| PREDICTED: similar to single-strand selective monofunctional uracil DNA...
0.0 [4..258] [46..300]
SMUG1_XENLA - Single-strand selective monofunctional uracil DNA glycosylase OS=Xenopus laevis GN=smug1 PE=1 SV=1
0.0 [23..258] [34..269]

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Predicted Domain #1
Region A:
Residues: [1-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY  60
   61 AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE 120
  121 HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA 180
  181 ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP 240
  241 SPRNPQANKG WEAVAKERLN ELGLLPLLLK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 119.0
Match: 1oe4A
Description: Single-strand selective monofunctional uracil-DNA glycosylase SMUG1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 5.22461096584694 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.68115068202636 bayes_pls_golite062009
uracil DNA N-glycosylase activity 4.48822773983461 bayes_pls_golite062009
single-strand selective uracil DNA N-glycosylase activity 3.83194769747125 bayes_pls_golite062009
hydrolase activity 2.80752243868997 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.59556365302624 bayes_pls_golite062009
structure-specific DNA binding 1.75635693402802 bayes_pls_golite062009
catalytic activity 1.59111295908728 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 1.34999321643757 bayes_pls_golite062009
binding 1.2276262882727 bayes_pls_golite062009
single-stranded DNA binding 1.14199628308287 bayes_pls_golite062009
nucleic acid binding 0.901890891144085 bayes_pls_golite062009
DNA binding 0.850361767185031 bayes_pls_golite062009
transcription regulator activity 0.543168797464517 bayes_pls_golite062009
damaged DNA binding 0.44704532195099 bayes_pls_golite062009
double-stranded DNA binding 0.307323249123648 bayes_pls_golite062009
protein binding 0.272261244770552 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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