YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: PFKFB1

General Information:
Name(s) found: PFKFB1 [HGNC (HUGO)]
Description(s) found:
Found 21 descriptions.
SHOW ALL
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 471 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPEMGELTQ TRLQKIWIPH SSGSSRLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST  60
   61 KLTRYLNWIG TPTKVFNLGQ YRREAVSYKN YEFFLPDNME ALQIRKQCAL AALKDVHNYL 120
  121 SHEEGHVAVF DATNTTRERR SLILQFAKEH GYKVFFIESI CNDPGIIAEN IRQVKLGSPD 180
  181 YIDCDREKVL EDFLKRIECY EVNYQPLDEE LDSHLSYIKI FDVGTRYMVN RVQDHIQSRT 240
  241 VYYLMNIHVT PRSIYLCRHG ESELNIRGRI GGDSGLSVRG KQYAYALANF IQSQGISSLK 300
  301 VWTSHMKRTI QTAEALGVPY EQWKALNEID AGVCEEMTYE EIQEHYPEEF ALRDQDKYRY 360
  361 RYPKGESYED LVQRLEPVIM ELERQENVLV ICHQAVMRCL LAYFLDKSSD ELPYLKCPLH 420
  421 TVLKLTPVAY GCKVESIYLN VEAVNTHREK PENVDITREP EEALDTVPAH Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..471] PSI-BLAST 159.0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 6-phosphofructo-2-kinase activity
    		•  5.42792629395033 bayes_pls_golite062009
  • fructose-2,6-bisphosphate 2-phosphatase activity
    		•  5.3758259177501 bayes_pls_golite062009
  • phosphofructokinase activity
    		•  4.74681837647377 bayes_pls_golite062009
  • phosphoglycerate mutase activity
    		•  3.38777226675734 bayes_pls_golite062009
  • fructose binding
    		•  2.65431677206223 bayes_pls_golite062009
  • fructose-6-phosphate binding
    		•  2.61827203165744 bayes_pls_golite062009
  • phosphatase activity
    		•  2.20711859657073 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.0220580269993 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  1.86382423322759 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.78167518994202 bayes_pls_golite062009
  • kinase activity
    		•  1.67050219347378 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  1.56016941506609 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.3848751235482 bayes_pls_golite062009
  • catalytic activity
    		•  1.37714494241232 bayes_pls_golite062009
  • hydrolase activity
    		•  1.32674664996211 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.24295845488314 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.08151102259045 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.974702705020209 bayes_pls_golite062009
  • intramolecular transferase activity, phosphotransferases
    		•  0.916759493094631 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.867181425037322 bayes_pls_golite062009
  • binding
    		•  0.864238150099353 bayes_pls_golite062009
  • transferase activity
    		•  0.709223678750312 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.688993364310212 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.656009904481476 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.64416740142962 bayes_pls_golite062009
  • GTP binding
    		•  0.643084645864898 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.561773791863863 bayes_pls_golite062009
  • DNA binding
    		•  0.522586598136164 bayes_pls_golite062009
  • GTPase activity
    		•  0.406399103964327 bayes_pls_golite062009
  • isomerase activity
    		•  0.275500708652009 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.261132792329283 bayes_pls_golite062009
  • protein binding
    		•  0.236742803345453 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.141310691160109 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0935614991493088 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0646123847220056 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0137537621821964 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle