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Protein Overview: PUS1

General Information:
Name(s) found: PUS1 [HGNC (HUGO)]
Description(s) found:
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  • gi|70166634|ref|NP_001002020.1| pseudouridine synthase 1 isoform 2 [Homo sapiens] [NCBI NR]
  • gi|70166599|ref|NP_001002019.1| pseudouridine synthase 1 isoform 2 [Homo sapiens] [NCBI NR]
  • gi|23503104|sp|Q9Y606|TRUA_HUMAN tRNA pseudouridine synthase A (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I) [NCBI NR]
  • gi|17939636|gb|AAH19320.1| Pseudouridylate synthase 1 [Homo sapiens] [NCBI NR]
  • gi|158257916|dbj|BAF84931.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|14550510|gb|AAH09505.1| Pseudouridylate synthase 1, isoform 1 [Homo sapiens] [NCBI NR]
  • ref|NP_079491.1| pseudouridylate synthase 1; pseudouridine synthase 1 [Homo sapiens] [NCBI NR]
  • gi|12804097|gb|AAH02901.1| Pseudouridylate synthase 1 [Homo sapiens] [NCBI NR]
  • pseudouridylate synthase 1 [HGNC (HUGO)]
  • (Q9Y606) tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I) [Swiss-Prot]
  • tRNA pseudouridine synthase A [hmr_yeast5_DM3-1_pombe.fasta]
  • pseudouridylate synthase 1; pseudouridine synthase 1 [HMR_022704.fasta]
  • PUS1 protein [Homo sapiens]gi|17939636|gb|AAH19320.1| Pseudouridylate synthase 1 [Homo sapiens]gi|14550510|gb|AAH09505.1| Pseudouridylate synthase 1 [Homo sapiens]gi|13376820|ref|NP_079491.1| pseudouridylate synthase 1; pseudouridine synthase 1 [Homo s [nrdb_11152004_Chlamydomonas]
  • tRNA pseudouridine synthase A (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 tRNA pseudouridine synthase A [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_025215) pseudouridylate synthase 1; pseudouridine synthase 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • pseudouridylate synthase 1 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • pseudouridylate synthase 1; pseudouridine synthase 1 [Homo sapiens] [HumanGallus06162005.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Pseudouridylate synthase 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 2 of tRNA pseudouridine synthase A [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 TRNA PSEUDOURIDINE SYNTHASE A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PUS1 Isoform 2 of tRNA pseudouridine synthase A [human-ipi-250309-contam.fasta]
  • pseudouridine synthase 1 isoform 2 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00001716.5|SWISS-PROT:Q9Y606-2|ENSEMBL:ENSP00000324726;ENSP00000392451;ENSP00000400032|REFSEQ:NP_001002019;NP_001002020|VEGA:OTTHUMP00000169905 Tax_Id=9606 Gene_Symbol=PUS1 Isoform 2 of tRNA pseudouridine synthase A [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • tRNA pseudouridine synthase A isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Isoform 2 of tRNA pseudouridine synthase A, mitochondrial OS=Homo sapiens GN=PUS1 [011711_HMR.fasta]
  • GeneSymbol=PUS1 Synonyms=MGC11268|MLASA1 tRNA pseudouridine synthase A, mitochondrial isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00001716.5|SWISS-PROT:Q9Y606-2|TREMBL:E5KMT6|ENSEMBL:ENSP00000392451;ENSP00000400032|REFSEQ:NP_001002019;NP_001002020|VEGA:OTTHUMP00000237726 Tax_Id=9606 Gene_Symbol=PUS1 Isoform 2 of tRNA pseudouridine synthase A, mitochondrial [ipi.HUMAN.20110912.fasta]
  • Isoform 2 of tRNA pseudouridine synthase A, mitochondrial GN=PUS1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=PUS1 Isoform 2 of tRNA pseudouridine synthase A, mitochondrial [human-ipi-270911-contam-BSA.fasta]
  • tRNA pseudouridine synthase OS=Homo sapiens PE=3 SV=1 [uniprot-human-031015-contam.fasta]
  • Isoform of Q9Y606, Isoform 2 of tRNA pseudouridine synthase A, mitochondrial OS=Homo sapiens GN=PUS1 [2016-04-human-contam-aPKC-His-Par6.fasta]
    • Organism: Homo sapiens
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNAEPPPA GAACPQDRRS CSGRAGGDRV WEDGEHPAKK LKSGGDEERR EKPPKRKIVL  60
   61 LMAYSGKGYH GMQRNVGSSQ FKTIEDDLVS ALVRSGCIPE NHGEDMRKMS FQRCARTDKG 120
  121 VSAAGQVVSL KVWLIDDILE KINSHLPSHI RILGLKRVTG GFNSKNRCDA RTYCYLLPTF 180
  181 AFAHKDRDVQ DETYRLSAET LQQVNRLLAC YKGTHNFHNF TSQKGPQDPS ACRYILEMYC 240
  241 EEPFVREGLE FAVIRVKGQS FMMHQIRKMV GLVVAIVKGY APESVLERSW GTEKVDVPKA 300
  301 PGLGLVLERV HFEKYNQRFG NDGLHEPLDW AQEEGKVAAF KEEHIYPTII GTERDERSMA 360
  361 QWLSTLPIHN FSATALTAGG TGAKVPSPLE GSEGDGDTD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..399] PSI-BLAST 82.522879 No description for 2nqpA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  5.19957135839682 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.78688422405974 bayes_pls_golite062009
  • isomerase activity
    		•  2.91720316078381 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31595692797262 bayes_pls_golite062009
  • catalytic activity
    		•  2.02180970970004 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.01176877679953 bayes_pls_golite062009
  • DNA binding
    		•  1.95629441517514 bayes_pls_golite062009
  • binding
    		•  1.32358464424761 bayes_pls_golite062009
  • transcription activator activity
    		•  1.27357280497723 bayes_pls_golite062009
  • protein binding
    		•  1.10318302423731 bayes_pls_golite062009
  • RNA binding
    		•  0.706879359688019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle