YRC Public Data Repository - Protein Structure Prediction

Protein:	PUS1
Organism:	Homo sapiens
Length:	399 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUS1.

Description	E-value	Query Range	Subject Range
PUS1 - pseudouridylate synthase 1	0.0	[1..399]	[29..427]
gi\|114647862 - gi\|114647862\|ref\|XP_001139560.1\| PREDICTED: hypothetical protein [Pan troglodytes]	0.0	[1..399]	[29..427]
gi\|109099290 - gi\|109099290\|ref\|XP_001113470.1\| PREDICTED: similar to pseudouridylate synthase 1 isoform 1 [Macaca ...	0.0	[1..399]	[85..483]
TRUA_RAT - tRNA pseudouridine synthase A, mitochondrial OS=Rattus norvegicus GN=Pus1 PE=1 SV=2	0.0	[1..399]	[31..423]
TRUA_MOUSE - tRNA pseudouridine synthase A, mitochondrial OS=Mus musculus GN=Pus1 PE=1 SV=2	0.0	[1..399]	[31..423]

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Predicted Domain #1

Region A:
Residues: [1-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNAEPPPA GAACPQDRRS CSGRAGGDRV WEDGEHPAKK LKSGGDEERR EKPPKRKIVL  60
   61 LMAYSGKGYH GMQRNVGSSQ FKTIEDDLVS ALVRSGCIPE NHGEDMRKMS FQRCARTDKG 120
  121 VSAAGQVVSL KVWLIDDILE KINSHLPSHI RILGLKRVTG GFNSKNRCDA RTYCYLLPTF 180
  181 AFAHKDRDVQ DETYRLSAET LQQVNRLLAC YKGTHNFHNF TSQKGPQDPS ACRYILEMYC 240
  241 EEPFVREGLE FAVIRVKGQS FMMHQIRKMV GLVVAIVKGY APESVLERSW GTEKVDVPKA 300
  301 PGLGLVLERV HFEKYNQRFG NDGLHEPLDW AQEEGKVAAF KEEHIYPTII GTERDERSMA 360
  361 QWLSTLPIHN FSATALTAGG TGAKVPSPLE GSEGDGDTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.522879
Match:	2nqpA
Description:	No description for 2nqpA was found.

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.19957135839682	bayes_pls_golite062009
intramolecular transferase activity	3.78688422405974	bayes_pls_golite062009
isomerase activity	2.91720316078381	bayes_pls_golite062009
transcription regulator activity	2.31595692797262	bayes_pls_golite062009
catalytic activity	2.02180970970004	bayes_pls_golite062009
nucleic acid binding	2.01176877679953	bayes_pls_golite062009
DNA binding	1.95629441517514	bayes_pls_golite062009
binding	1.32358464424761	bayes_pls_golite062009
transcription activator activity	1.27357280497723	bayes_pls_golite062009
protein binding	1.10318302423731	bayes_pls_golite062009
RNA binding	0.706879359688019	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: