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Protein Overview: ETS1

General Information:
Name(s) found: ETS1 [HGNC (HUGO)]
Description(s) found:
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  • pir||TVHUET transcription factor ets-1, splice form a - human [NCBI NR]
  • gi|54695774|gb|AAV38259.1| v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [Homo sapiens] [NCBI NR]
  • gi|4885219|ref|NP_005229.1| v-ets erythroblastosis virus E26 oncogene homolog 1 isoform 2 [Homo sapiens] [NCBI NR]
  • gi|29882|emb|CAA32904.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|182269|gb|AAA52410.1| ets-1 protein [Homo sapiens] [NCBI NR]
  • gi|119641|sp|P14921.1|ETS1_HUMAN RecName: Full=Protein C-ets-1; AltName: Full=p54 [NCBI NR]
  • gi|119588115|gb|EAW67711.1| v-ets erythroblastosis virus E26 oncogene homolog 1 (avian), isoform CRA_c [Homo sapiens] [NCBI NR]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [HGNC (HUGO)]
  • Protein C-ets-1 OS=Homo sapiens GN=ETS1 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform c-ETS-1A of P14921 [hmr_yeast5_DM3-1_pombe.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1; Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis v [HMR_022704.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1; Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); v-ets avian erythrob [071204_hmrz_cont.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [Homo sapiens]gi|4885219|ref|NP_005229.1| v-ets erythroblastosis virus E26 oncogene homolog 1 [Homo sapiens]gi|68890|pir||TVHUET transcription factor ets-1, splice form a - humangi|29882|emb|C [nrdb_11152004_Chlamydomonas]
  • C-ets-1 protein (p54) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform c-ETS-1A of C-ets-1 protein [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005238) v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-et [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Protein C-ets-1 (p54) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian), isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ets-1 protein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform c-ETS-1A of C-ets-1 protein [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF C-ETS-1 PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • v-ets erythroblastosis virus E26 oncogene homolog 1 isoform 2 [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=ETS1 Isoform c-ETS-1A of Protein C-ets-1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00028127.1|SWISS-PROT:P14921-1|TREMBL:A8K725;B4DW78;Q5U0M2;Q6FG54;Q96AC5|ENSEMBL:ENSP00000324578|REFSEQ:NP_005229|H-INV:HIT000321464 Tax_Id=9606 Gene_Symbol=ETS1 Isoform c-ETS-1A of Protein C-ets-1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • protein C-ets-1 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P14921;Q14278;Q16080; RecName: Full=Protein C-ets-1; AltName: Full=p54; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform c-ETS-1A of Protein C-ets-1 OS=Homo sapiens GN=ETS1 [011711_HMR.fasta]
  • GeneSymbol=ETS1 Synonyms=ETS-1|EWSR2|FLJ10768 protein C-ets-1 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00028127.1|SWISS-PROT:P14921-1|TREMBL:A8K725;B4DW78;Q5U0M2;Q6FG54|ENSEMBL:ENSP00000324578|REFSEQ:NP_005229|H-INV:HIT000321464|VEGA:OTTHUMP00000231011 Tax_Id=9606 Gene_Symbol=ETS1 Isoform c-ETS-1A of Protein C-ets-1 [ipi.HUMAN.20110912.fasta]
  • Protein C-ets-1 GN=ETS1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 441 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ  60
   61 QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 120
  121 VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 180
  181 ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 240
  241 TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 300
  301 KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 360
  361 WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS 420
  421 LLGYTPEELH AMLDVKPDAD E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] PSI-BLAST 40.0 No description for 2jv3A was found.
    2 View Details [142..205] deduced N/A No confident structure predictions are available.
    3 View Details [206..441] PSI-BLAST 57.30103 ETS-1 transcription factor, residues 331-440

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle