Protein Overview: HSD17B4

General Information:
Name(s) found:	HSD17B4 [HGNC (HUGO)]
Description(s) found: Found 32 descriptions. SHOW ALL	hydroxysteroid (17-beta) dehydrogenase 4 [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	736 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE  60
   61 EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH 120
  121 RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI 180
  181 EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG 240
  241 AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS 300
  301 KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD 360
  361 LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA 420
  421 GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV 480
  481 AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS 540
  541 ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN 600
  601 AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI 660
  661 GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI 720
  721 MLSQKLQMIL KDYAKL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..318]	PSI-BLAST	74.30103	(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4
2	View Details	[319..387]	FFAS03	2.79	Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
3	View Details	[388..615]	PSI-BLAST	111.0	Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
4	View Details	[616..736]	PSI-BLAST	47.69897	SCP2-like domain of MFE-2

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
binding	0.116896827329077	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.60197973503923	bayes_pls_golite062009
CoA hydrolase activity	2.3187640589669	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.14159464719086	bayes_pls_golite062009
thiolester hydrolase activity	1.14125301545576	bayes_pls_golite062009
catalytic activity	0.74605540351792	bayes_pls_golite062009
binding	0.475677115073074	bayes_pls_golite062009
hydrolase activity	0.093543122203219	bayes_pls_golite062009
protein binding	0.0641694633066071	bayes_pls_golite062009

4

Term	Confidence	Notes
	2.71257188213841	bayes_pls_golite062009
sterol carrier protein X-related thiolase activity	2.46442588113447	bayes_pls_golite062009
sterol binding	2.24666178533847	bayes_pls_golite062009
steroid binding	1.67242619480107	bayes_pls_golite062009
binding	1.5623970659833	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.86283765215999	bayes_pls_golite062009
steroid dehydrogenase activity	0.851413098259232	bayes_pls_golite062009
protein binding	0.631472138953975	bayes_pls_golite062009
lipid binding	0.612082389575099	bayes_pls_golite062009
catalytic activity	0.334051377480817	bayes_pls_golite062009
oxidoreductase activity	0.0374694704754488	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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