YRC Public Data Repository - Protein Structure Prediction

Protein:	HSD17B4
Organism:	Homo sapiens
Length:	736 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSD17B4.

Description	E-value	Query Range	Subject Range
gi\|126352659, gi... - gi\|45775304\|gb\|AAS77255.1\| 17 beta-hydroxysteroid dehydrogenase type 4 [Equus caballus], gi\|12635265...	0.0	[1..736]	[1..735]
gi\|113911805 - gi\|113911805\|gb\|AAI22585.1\| Hydroxysteroid (17-beta) dehydrogenase 4 [Bos taurus]	0.0	[1..736]	[1..736]
gi\|73970527 - gi\|73970527\|ref\|XP_531860.2\| PREDICTED: similar to Peroxisomal multifunctional enzyme type 2 (MFE-2)...	0.0	[1..736]	[1..737]
gi\|109078303 - gi\|109078303\|ref\|XP_001087837.1\| PREDICTED: hydroxysteroid (17-beta) dehydrogenase 4 isoform 1 [Maca...	0.0	[1..736]	[1..734]
gi\|1881831 - gi\|1881831\|gb\|AAB49519.1\| 17 beta-hydroxysteroid dehydrogenase type IV; HSD IV [Rattus sp.] DHB4_RAT - Peroxisomal multifunctional enzyme type 2 OS=Rattus norvegicus GN=Hsd17b4 PE=1 SV=3	0.0	[1..736]	[1..735]
DHB4_MOUSE - Peroxisomal multifunctional enzyme type 2 OS=Mus musculus GN=Hsd17b4 PE=1 SV=3	0.0	[1..736]	[1..735]

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Predicted Domain #1

Region A:
Residues: [1-318]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE  60
   61 EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH 120
  121 RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI 180
  181 EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG 240
  241 AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS 300
  301 KIDSEGGVSA NHTSRATS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.30103
Match:	1gz6A
Description:	(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
binding	0.116896827329077	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [319-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TATSGFAGAI GQKLPPFSYA YTELEAIMYA LGVGASIKDP KDLKFIYEGS SDFSCLPTFG  60
   61 VIIGQKSMM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.79
Match:	1s9cA
Description:	Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [388-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGLAEIPGL SINFAKVLHG EQYLELYKPL PRAGKLKCEA VVADVLDKGS GVVIIMDVYS  60
   61 YSEKELICHN QFSLFLVGSG GFGGKRTSDK VKVAVAIPNR PPDAVLTDTT SLNQAALYRL 120
  121 SGDWNPLHID PNFASLAGFD KPILHGLCTF GFSARRVLQQ FADNDVSRFK AIKARFAKPV 180
  181 YPGQTLQTEM WKEGNRIHFQ TKVQETGDIV ISNAYVDLAP TSGTSAKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	1s9cA
Description:	Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.60197973503923	bayes_pls_golite062009
CoA hydrolase activity	2.3187640589669	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.14159464719086	bayes_pls_golite062009
thiolester hydrolase activity	1.14125301545576	bayes_pls_golite062009
catalytic activity	0.74605540351792	bayes_pls_golite062009
binding	0.475677115073074	bayes_pls_golite062009
hydrolase activity	0.093543122203219	bayes_pls_golite062009
protein binding	0.0641694633066071	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [616-736]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSEGGKLQST FVFEEIGRRL KDIGPEVVKK VNAVFEWHIT KGGNIGAKWT IDLKSGSGKV  60
   61 YQGPAKGAAD TTIILSDEDF MEVVLGKLDP QKAFFSGRLK ARGNIMLSQK LQMILKDYAK 120
  121 L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1iktA
Description:	SCP2-like domain of MFE-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
	2.71257188213841	bayes_pls_golite062009
sterol carrier protein X-related thiolase activity	2.46442588113447	bayes_pls_golite062009
sterol binding	2.24666178533847	bayes_pls_golite062009
steroid binding	1.67242619480107	bayes_pls_golite062009
binding	1.5623970659833	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.86283765215999	bayes_pls_golite062009
steroid dehydrogenase activity	0.851413098259232	bayes_pls_golite062009
protein binding	0.631472138953975	bayes_pls_golite062009
lipid binding	0.612082389575099	bayes_pls_golite062009
catalytic activity	0.334051377480817	bayes_pls_golite062009
oxidoreductase activity	0.0374694704754488	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: