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Protein Overview: PRKCE

General Information:
Name(s) found: PRKCE [HGNC (HUGO)]
Description(s) found:
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  • gi|80476652|gb|AAI09035.1| Protein kinase C, epsilon [Homo sapiens] [NCBI NR]
  • gi|80474928|gb|AAI09034.1| Protein kinase C, epsilon [Homo sapiens] [NCBI NR]
  • gi|4885563|ref|NP_005391.1| protein kinase C, epsilon [Homo sapiens] [NCBI NR]
  • gi|400135|sp|Q02156.1|KPCE_HUMAN RecName: Full=Protein kinase C epsilon type; AltName: Full=nPKC-epsilon [NCBI NR]
  • gi|35495|emb|CAA46388.1| protein kinase C epsilon [Homo sapiens] [NCBI NR]
  • pir||S28942 protein kinase C (EC 2.7.1.-) epsilon - human [NCBI NR]
  • gi|166706817|gb|ABY87556.1| protein kinase C, epsilon [Homo sapiens] [NCBI NR]
  • gi|119620663|gb|EAX00258.1| protein kinase C, epsilon, isoform CRA_b [Homo sapiens] [NCBI NR]
  • protein kinase C, epsilon [HGNC (HUGO)]
  • Protein kinase C epsilon type OS=Homo sapiens GN=PRKCE PE=1 SV=1 [Swiss-Prot]
  • Protein kinase C, epsilon type [hmr_yeast5_DM3-1_pombe.fasta]
  • protein kinase C, epsilon [Homo sapiens]gi|35495|emb|CAA46388.1| protein kinase C epsilon [Homo sapiens]gi|400135|sp|Q02156|KPCE_HUMAN Protein kinase C, epsilon type (nPKC-epsilon)gi|346317|pir||S28942 protein kinase C (EC 2.7.1.-) epsilon - human [nrdb_11152004_Chlamydomonas]
  • Protein kinase C, epsilon type (nPKC-epsilon) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Protein kinase C epsilon type [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005400) protein kinase C, epsilon [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • protein kinase C, epsilon [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Protein kinase C, epsilon type [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • Protein kinase C epsilon type (nPKC-epsilon) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • protein kinase C, epsilon, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Protein kinase C, epsilon [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • protein kinase C epsilon [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PROTEIN KINASE C, EPSILON TYPE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PRKCE Protein kinase C epsilon type [human-ipi-250309-contam.fasta]
  • IPI:IPI00024539.1|SWISS-PROT:Q02156|TREMBL:B0LPH7;B2R9M7|ENSEMBL:ENSP00000306124|REFSEQ:NP_005391|H-INV:HIT000339202|VEGA:OTTHUMP00000159032 Tax_Id=9606 Gene_Symbol=PRKCE Protein kinase C epsilon type [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PRKCE Protein kinase C epsilon type ENSG00000171132 IPI00024539 IPI00794086 [drosphohumanreversed.fasta]
  • protein kinase C epsilon type [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q02156;B0LPH7;Q32MQ3;Q53SL4;Q53SM5;Q9UE81; RecName: Full=Protein kinase C epsilon type; AltName: Full=nPKC-epsilon; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Protein kinase C epsilon type OS=Homo sapiens GN=PRKCE [011711_HMR.fasta]
  • IPI:IPI00024539.1|SWISS-PROT:Q02156|TREMBL:B2R9M7|ENSEMBL:ENSP00000306124|REFSEQ:NP_005391|H-INV:HIT000339202|VEGA:OTTHUMP00000159032 Tax_Id=9606 Gene_Symbol=PRKCE Protein kinase C epsilon type [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PRKCE Synonyms=MGC125656|MGC125657|PKCE|nPKC-epsilon protein kinase C epsilon type [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Protein kinase C epsilon type GN=PRKCE [Doctor+uniprot-HUMAN-120911.fasta]
  • Protein kinase C epsilon type OS=Homo sapiens GN=PRKCE PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 737 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT  60
   61 NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
  121 PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180
  181 TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN 240
  241 MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300
  301 KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE 360
  361 NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG 420
  421 KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD 480
  481 RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL 540
  541 DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM 600
  601 MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED 660
  661 AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI 720
  721 NQEEFKGFSY FGEDLMP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 12.30103 Domain from protein kinase C epsilon
    2 View Details [136..265] FFAS03 3.22 Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
    3 View Details [266..677] PSI-BLAST 47.0 No description for 2ozoA was found.
    4 View Details [678..737] PSI-BLAST 82.0 No description for 2i0eA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • calcium-dependent phospholipid binding
    		•  4.44639260287301 bayes_pls_golite062009
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • phospholipid binding
    		•  2.74013385479058 bayes_pls_golite062009
  • protein binding
    		•  2.38962673708753 bayes_pls_golite062009
  • neurexin binding
    		•  1.99616093461872 bayes_pls_golite062009
  • receptor activity
    		•  1.8680110497448 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.5224906678897 bayes_pls_golite062009
  • signal transducer activity
    		•  1.5224906678897 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • profilin binding
    		•  1.32619249806841 bayes_pls_golite062009
  • transporter activity
    		•  1.2628067945512 bayes_pls_golite062009
  • cation binding
    		•  0.860272194694588 bayes_pls_golite062009
  • metal ion binding
    		•  0.860272194694588 bayes_pls_golite062009
  • ion binding
    		•  0.853522493520737 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.816751946072324 bayes_pls_golite062009
  • calmodulin binding
    		•  0.66928366000251 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.655976398483981 bayes_pls_golite062009
  • hydrolase activity
    		•  0.501946993060588 bayes_pls_golite062009
  • SNARE binding
    		•  0.3731056408292 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.82097223032126 bayes_pls_golite062009
  • binding
    		•  2.71288992341677 bayes_pls_golite062009
  • protein binding
    		•  2.2604757016607 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.18539532628368 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.07238897772131 bayes_pls_golite062009
  • DNA binding
    		•  2.05972958088217 bayes_pls_golite062009
  • kinase activity
    		•  2.00903309297046 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91592331431516 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.83466699022067 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66598460953658 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66598460953658 bayes_pls_golite062009
  • protein kinase activity
    		•  1.61903873760762 bayes_pls_golite062009
  • transferase activity
    		•  1.45394179515146 bayes_pls_golite062009
  • transcription factor activity
    		•  1.38590948364516 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.12412426198961 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.10707685935826 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  1.04998401151243 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.969266093401353 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.93378879973188 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.717794523788476 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.6091533221871 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.442062495186646 bayes_pls_golite062009
  • kinase binding
    		•  0.409606963040614 bayes_pls_golite062009
  • cation binding
    		•  0.311967762495891 bayes_pls_golite062009
  • metal ion binding
    		•  0.311967762495891 bayes_pls_golite062009
  • ion binding
    		•  0.307697800147455 bayes_pls_golite062009
  • catalytic activity
    		•  0.216721136299042 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle