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Protein Overview: POU1F1

General Information:
Name(s) found: POU1F1 [HGNC (HUGO)]
Description(s) found:
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  • gi|4505955|ref|NP_000297.1| pituitary specific transcription factor 1 isoform alpha [Homo sapiens] [NCBI NR]
  • gi|35475|emb|CAA44295.1| transcription factor [Homo sapiens] [NCBI NR]
  • gi|219998|dbj|BAA01068.1| Pit-1/GHF-1 [Homo sapiens] [NCBI NR]
  • gi|123408|sp|P28069.1|PIT1_HUMAN RecName: Full=Pituitary-specific positive transcription factor 1; Short=Pit-1; AltName: Full=Growth hormone factor 1; Short=GHF-1 [NCBI NR]
  • gi|119589272|gb|EAW68866.1| POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), isoform CRA_a [Homo sapiens] [NCBI NR]
  • pir||S18718 transcription factor Pit-1 - human [NCBI NR]
  • POU class 1 homeobox 1 [HGNC (HUGO)]
  • Pituitary-specific positive transcription factor 1 OS=Homo sapiens GN=POU1F1 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform B of P28069 [hmr_yeast5_DM3-1_pombe.fasta]
  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) [HMR_022704.fasta]
  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) [Homo sapiens]gi|107930|pir||S18718 transcription factor Pit-1 - humangi|35475|emb|CAA44295.1| transcription factor [Homo sapiens]gi|123408|sp|P28069|PIT1_HUMAN Pituitary-speci [nrdb_11152004_Chlamydomonas]
  • Pituitary-specific positive transcription factor 1 (Pit-1) (Growth hormone factor 1) (GHF-1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform B of Pituitary-specific positive transcription factor 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000306) POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • pituitary specific transcription factor 1 isoform alpha [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Pit-1/GHF-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • transcription factor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform B of Pituitary-specific positive transcription factor 1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF PITUITARY-SPECIFIC POSITIVE TRANSCRIPTION FACTOR 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=POU1F1 Isoform B of Pituitary-specific positive transcription factor 1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00000794.1|SWISS-PROT:P28069-1|ENSEMBL:ENSP00000263781|REFSEQ:NP_000297|H-INV:HIT000100419|VEGA:OTTHUMP00000171911 Tax_Id=9606 Gene_Symbol=POU1F1 Isoform B of Pituitary-specific positive transcription factor 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • pituitary-specific positive transcription factor 1 isoform alpha [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P28069;O75757;Q15132;Q15133;Q9UD34;Q9UEL3; RecName: Full=Pituitary-specific positive transcription factor 1; AltName: Full=Growth hormone factor 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform B of Pituitary-specific positive transcription factor 1 OS=Homo sapiens GN=POU1F1 [011711_HMR.fasta]
  • GeneSymbol=POU1F1 Synonyms=CPHD1|GHF-1|PIT1|POU1F1a|Pit-1 pituitary-specific positive transcription factor 1 isoform alpha [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00000794.1|SWISS-PROT:P28069-1|ENSEMBL:ENSP00000263781|REFSEQ:NP_000297|H-INV:HIT000100419|VEGA:OTTHUMP00000213820 Tax_Id=9606 Gene_Symbol=POU1F1 Isoform B of Pituitary-specific positive transcription factor 1 [ipi.HUMAN.20110912.fasta]
  • Pituitary-specific positive transcription factor 1 GN=POU1F1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 291 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTATG LHYSVPSCHY  60
   61 GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPIHQPLLAE DPTAADFKQE LRRKSKLVEE 120
  121 PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF 180
  181 KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS 240
  241 SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] deduced N/A No confident structure predictions are available.
    2 View Details [138..291] PSI-BLAST 26.39794 Pit-1 POU homeodomain; Pit-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle