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Protein Overview: LMAN1

General Information:
Name(s) found: LMAN1 [HGNC (HUGO)]
Description(s) found:
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  • gi|606828|gb|AAA95960.1| mannose-specific lectin [NCBI NR]
  • gi|5031873|ref|NP_005561.1| lectin, mannose-binding, 1 precursor [Homo sapiens] [NCBI NR]
  • gi|22261801|sp|P49257.2|LMAN1_HUMAN RecName: Full=Protein ERGIC-53; AltName: Full=ER-Golgi intermediate compartment 53 kDa protein; AltName: Full=Lectin mannose-binding 1; AltName: Full=Gp58; AltName: Full=Intracellular mannose-specific lectin MR60; Flags [NCBI NR]
  • gi|119583502|gb|EAW63098.1| lectin, mannose-binding, 1, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119583501|gb|EAW63097.1| lectin, mannose-binding, 1, isoform CRA_b [Homo sapiens] [NCBI NR]
  • lectin, mannose-binding, 1 [HGNC (HUGO)]
  • Protein ERGIC-53 OS=Homo sapiens GN=LMAN1 PE=1 SV=2 [Swiss-Prot]
  • (P49257) ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (Gp58) (Intracellular mannose specific lectin MR60) [Swiss-Prot]
  • ERGIC-53 protein precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • lectin, mannose-binding, 1 precursor; intracellular mannose specific lectin; endoplasmic reticulum-golgi intermediate compartment protein 53 [HMR_022704.fasta]
  • lectin, mannose-binding, 1 precursor; endoplasmic reticulum-golgi intermediate compartment protein 53; intracellular mannose specific lectin [Human2242005.fasta]
  • lectin, mannose-binding, 1 precursor [Homo sapiens]gi|22261801|sp|P49257|ER53_HUMAN ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (Gp58) (Intracellular mannose specific lectin MR60)gi|606828|gb [nrdb_11152004_Chlamydomonas]
  • ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (Gp58) (Intracellular mannose specific lectin MR60) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 ERGIC-53 protein precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005570) lectin, mannose-binding, 1 precursor; intracellular mannose specific lectin; endoplasmic reticulum-golgi intermediate compartment protein 53 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • lectin, mannose-binding, 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • lectin, mannose-binding, 1 precursor; endoplasmic reticulum-golgi intermediate compartment protein 53; intracellular mannose specific lectin [Homo sapiens] [HumanGallus06162005.fasta]
  • lectin, mannose-binding, 1 precursor; intracellular mannose specific lectin; endoplasmic reticulum-golgi intermediate compartment protein 53 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Protein ERGIC-53 precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (Gp58) (Intracellular mannose-specific lectin MR60) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • lectin, mannose-binding, 1, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mannose-specific lectin [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 ERGIC-53 PROTEIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LMAN1 Protein ERGIC-53 [human-ipi-250309-contam.fasta]
  • ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (Gp58) (Intracellular mannose-specific lectin MR60) [nr-271106-contam.fasta]
  • IPI:IPI00026530.4|SWISS-PROT:P49257|TREMBL:A0PJ85;B2R774;B4DVV0;Q53FS4|ENSEMBL:ENSP00000251047|REFSEQ:NP_005561|H-INV:HIT000217931|VEGA:OTTHUMP00000073585;OTTHUMP00000163644 Tax_Id=9606 Gene_Symbol=LMAN1 Protein ERGIC-53 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=LMAN1 Protein ERGIC-53 precursor ENSG00000074695 IPI00026530 IPI00647732 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LMAN1 ERGIC-53 protein precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • protein ERGIC-53 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P49257;Q12895;Q8N5I7;Q9UQG1;Q9UQG2;Q9UQG3;Q9UQG4;Q9UQG5;Q9UQG6;Q9UQG7;Q9UQG8;Q9UQG9;Q9UQH0;Q9UQH1;Q9UQH2; RecName: Full=Protein ERGIC-53; AltName: Full=ER-Golgi intermediate compartment 53 kDa protein; AltName: Full=Lectin mannose-binding 1; AltName: Full=Gp58; AltName: Full=Intracellular mannose-specific lectin MR60; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Protein ERGIC-53 OS=Homo sapiens GN=LMAN1 [011711_HMR.fasta]
  • GeneSymbol=LMAN1 Synonyms=ERGIC-53|ERGIC53|F5F8D|FMFD1|MCFD1|MR60|gp58 protein ERGIC-53 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00026530.4|SWISS-PROT:P49257|TREMBL:A0PJ85;B2R774;B4DVV0;Q53FS4|ENSEMBL:ENSP00000251047|REFSEQ:NP_005561|H-INV:HIT000217931|VEGA:OTTHUMP00000163644 Tax_Id=9606 Gene_Symbol=LMAN1 Protein ERGIC-53 [ipi.HUMAN.20110912.fasta]
  • Protein ERGIC-53 GN=LMAN1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Lectin, mannose-binding, 1, isoform CRA_b OS=Homo sapiens GN=LMAN1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGSRQRGLR ARVRPLFCAL LLSLGRFVRG DGVGGDPAVA LPHRRFEYKY SFKGPHLVQS  60
   61 DGTVPFWAHA GNAIPSSDQI RVAPSLKSQR GSVWTKTKAA FENWEVEVTF RVTGRGRIGA 120
  121 DGLAIWYAEN QGLEGPVFGS ADLWNGVGIF FDSFDNDGKK NNPAIVIIGN NGQIHYDHQN 180
  181 DGASQALASC QRDFRNKPYP VRAKITYYQN TLTVMINNGF TPDKNDYEFC AKVENMIIPA 240
  241 QGHFGISAAT GGLADDHDVL SFLTFQLTEP GKEPPTPDKE ISEKEKEKYQ EEFEHFQQEL 300
  301 DKKKEEFQKG HPDLQGQPAE EIFESVGDRE LRQVFEGQNR IHLEIKQLNR QLDMILDEQR 360
  361 RYVSSLTEEI SKRGAGMPGQ HGQITQQELD TVVKTQHEIL RQVNEMKNSM SETVRLVSGM 420
  421 QHPGSAGGVY ETTQHFIDIK EHLHIVKRDI DNLVQRNMPS NEKPKCPELP PFPSCLSTVH 480
  481 FIIFVVVQTV LFIGYIMYRS QQEAAAKKFF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] PSI-BLAST 56.0 The Crystal structure of the Carbohydrate recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals a novel metal binding site and conformational changes associated with calcium ion binding
    2 View Details [280..468] PSI-BLAST 6.522879 Heavy meromyosin subfragment
    3 View Details [469..510] MSA 2.122991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.77315480906007 bayes_pls_golite062009
  • sugar binding
    		•  1.53959484116223 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.40439904952516 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • protein binding
    		•  0.657665757061848 bayes_pls_golite062009
  • signal transducer activity
    		•  0.631926547812897 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.631926547812897 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.5678336426881 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.546870122670733 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.534220865159691 bayes_pls_golite062009
  • receptor activity
    		•  0.23954333371021 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00800219256384116 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle