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Protein Overview: BRF1

General Information:
Name(s) found: BRF1 [HGNC (HUGO)]
Description(s) found:
Found 28 descriptions.
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  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 677 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL  60
   61 DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR 120
  121 HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA 180
  181 IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH 240
  241 DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK 300
  301 LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC 360
  361 GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS 420
  421 LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE 480
  481 YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY 540
  541 SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP 600
  601 AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ 660
  661 MMGSNDYGCD GDEDDGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..290] PSI-BLAST 37.154902 No description for 2g9xB was found.
    2 View Details [291..385] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [386..489] FFAS03 2.69 TBP-binding domain of the transcription factor IIIb Brf1 subunit
    4 View Details [490..677] MSA 4.235996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.34389570239956 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  3.19553060844126 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  2.87088741581791 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.795846725429 bayes_pls_golite062009
  • binding
    		•  2.4204867358489 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.04886889839181 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00665312545368 bayes_pls_golite062009
  • DNA binding
    		•  1.94297811210385 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.69439693414478 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.65109787211976 bayes_pls_golite062009
  • protein binding
    		•  1.47106731485576 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21921365719206 bayes_pls_golite062009
  • RNA binding
    		•  1.02001545745027 bayes_pls_golite062009
  • transcription factor binding
    		•  0.749278791251235 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.729629809946521 bayes_pls_golite062009
  • positive transcription elongation factor activity
    		•  0.42590121577004 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.138191616709499 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0696060248241566 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle