Protein Overview: HHIP

General Information:
Name(s) found:	HHIP [HGNC (HUGO)]
Description(s) found: Found 26 descriptions. SHOW ALL	hedgehog interacting protein [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	700 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKMLSFKLL LLAVALGFFE GDAKFGERNE GSGARRRRCL NGNPPKRLKR RDRRMMSQLE  60
   61 LLSGGEMLCG GFYPRLSCCL RSDSPGLGRL ENKIFSVTNN TECGKLLEEI KCALCSPHSQ 120
  121 SLFHSPEREV LERDLVLPLL CKDYCKEFFY TCRGHIPGFL QTTADEFCFY YARKDGGLCF 180
  181 PDFPRKQVRG PASNYLDQME EYDKVEEISR KHKHNCFCIQ EVVSGLRQPV GALHSGDGSQ 240
  241 RLFILEKEGY VKILTPEGEI FKEPYLDIHK LVQSGIKGGD ERGLLSLAFH PNYKKNGKLY 300
  301 VSYTTNQERW AIGPHDHILR VVEYTVSRKN PHQVDLRTAR VFLEVAELHR KHLGGQLLFG 360
  361 PDGFLYIILG DGMITLDDME EMDGLSDFTG SVLRLDVDTD MCNVPYSIPR SNPHFNSTNQ 420
  421 PPEVFAHGLH DPGRCAVDRH PTDININLTI LCSDSNGKNR SSARILQIIK GKDYESEPSL 480
  481 LEFKPFSNGP LVGGFVYRGC QSERLYGSYV FGDRNGNFLT LQQSPVTKQW QEKPLCLGTS 540
  541 GSCRGYFSGH ILGFGEDELG EVYILSSSKS MTQTHNGKLY KIVDPKRPLM PEECRATVQP 600
  601 AQTLTSECSR LCRNGYCTPT GKCCCSPGWE GDFCRTAKCE PACRHGGVCV RPNKCLCKKG 660
  661 YLGPQCEQVD RNIRRVTRAG ILDQIIDMTS YLLDLTSYIV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..71]	deduced	N/A	No confident structure predictions are available.
2	View Details	[72..197]	FFAS03	1.08	Secreted Frizzled-related protein 3 (SFRP-3;fzb)
3	View Details	[198..320]	PSI-BLAST	34.30103	No description for 2g8sA was found.
4	View Details	[321..700]	PSI-BLAST	14.39794	Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transmembrane receptor activity	4.12744895314187	bayes_pls_golite062009
receptor activity	3.87682364042772	bayes_pls_golite062009
signal transducer activity	3.01939524477326	bayes_pls_golite062009
molecular transducer activity	3.01939524477326	bayes_pls_golite062009
Wnt receptor activity	2.31013454239678	bayes_pls_golite062009
binding	1.52480092026779	bayes_pls_golite062009
Wnt-protein binding	1.42144939971845	bayes_pls_golite062009
protein binding	1.03919942773652	bayes_pls_golite062009

3

No functions predicted.

4

Term	Confidence	Notes
ErbB-2 class receptor binding	5.19651613164447	bayes_pls_golite062009
ErbB-3 class receptor binding	4.63578487982286	bayes_pls_golite062009
receptor binding	3.53758205836051	bayes_pls_golite062009
epidermal growth factor receptor binding	3.23778562911102	bayes_pls_golite062009
growth factor activity	2.87784288183287	bayes_pls_golite062009
binding	2.33940742543305	bayes_pls_golite062009
protein binding	1.97546801934296	bayes_pls_golite062009
glycosaminoglycan binding	1.68773803817361	bayes_pls_golite062009
signal transducer activity	1.66401431847753	bayes_pls_golite062009
molecular transducer activity	1.66401431847753	bayes_pls_golite062009
heparin binding	1.66121757844416	bayes_pls_golite062009
polysaccharide binding	1.45011422686075	bayes_pls_golite062009
pattern binding	1.285853711507	bayes_pls_golite062009
transcription factor binding	0.795087651578297	bayes_pls_golite062009
glycoprotein binding	0.488553067572279	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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