YRC Public Data Repository - Protein Structure Prediction

Protein:	HHIP
Organism:	Homo sapiens
Length:	700 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HHIP.

Description	E-value	Query Range	Subject Range
gi\|109075780 - gi\|109075780\|ref\|XP_001093950.1\| PREDICTED: similar to hedgehog-interacting protein [Macaca mulatta]	0.0	[1..700]	[1..700]
HHIP - hedgehog interacting protein	0.0	[1..700]	[1..700]
gi\|114596263 - gi\|114596263\|ref\|XP_001146476.1\| PREDICTED: hedgehog-interacting protein [Pan troglodytes]	0.0	[1..700]	[1..700]
gi\|62665103 - gi\|62665103\|ref\|XP_238042.3\| PREDICTED: similar to Hedgehog-interacting protein precursor (HHIP) (HI...	0.0	[1..700]	[1..700]
gi\|26327663 - gi\|26327663\|dbj\|BAC27575.1\| unnamed protein product [Mus musculus]	0.0	[1..700]	[1..700]
gi\|73977794 - gi\|73977794\|ref\|XP_532677.2\| PREDICTED: similar to hedgehog-interacting protein isoform 1 [Canis fam...	0.0	[1..700]	[1..700]

Back

Predicted Domain #1

Region A:
Residues: [1-71]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKMLSFKLL LLAVALGFFE GDAKFGERNE GSGARRRRCL NGNPPKRLKR RDRRMMSQLE  60
   61 LLSGGEMLCG G

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [72-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FYPRLSCCLR SDSPGLGRLE NKIFSVTNNT ECGKLLEEIK CALCSPHSQS LFHSPEREVL  60
   61 ERDLVLPLLC KDYCKEFFYT CRGHIPGFLQ TTADEFCFYY ARKDGGLCFP DFPRKQVRGP 120
  121 ASNYLD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.08
Match:	1ijxA
Description:	Secreted Frizzled-related protein 3 (SFRP-3;fzb)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	4.12744895314187	bayes_pls_golite062009
receptor activity	3.87682364042772	bayes_pls_golite062009
signal transducer activity	3.01939524477326	bayes_pls_golite062009
molecular transducer activity	3.01939524477326	bayes_pls_golite062009
Wnt receptor activity	2.31013454239678	bayes_pls_golite062009
binding	1.52480092026779	bayes_pls_golite062009
Wnt-protein binding	1.42144939971845	bayes_pls_golite062009
protein binding	1.03919942773652	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [198-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMEEYDKVEE ISRKHKHNCF CIQEVVSGLR QPVGALHSGD GSQRLFILEK EGYVKILTPE  60
   61 GEIFKEPYLD IHKLVQSGIK GGDERGLLSL AFHPNYKKNG KLYVSYTTNQ ERWAIGPHDH 120
  121 ILR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.30103
Match:	2g8sA
Description:	No description for 2g8sA was found.

Predicted Domain #4

Region A:
Residues: [321-700]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVEYTVSRKN PHQVDLRTAR VFLEVAELHR KHLGGQLLFG PDGFLYIILG DGMITLDDME  60
   61 EMDGLSDFTG SVLRLDVDTD MCNVPYSIPR SNPHFNSTNQ PPEVFAHGLH DPGRCAVDRH 120
  121 PTDININLTI LCSDSNGKNR SSARILQIIK GKDYESEPSL LEFKPFSNGP LVGGFVYRGC 180
  181 QSERLYGSYV FGDRNGNFLT LQQSPVTKQW QEKPLCLGTS GSCRGYFSGH ILGFGEDELG 240
  241 EVYILSSSKS MTQTHNGKLY KIVDPKRPLM PEECRATVQP AQTLTSECSR LCRNGYCTPT 300
  301 GKCCCSPGWE GDFCRTAKCE PACRHGGVCV RPNKCLCKKG YLGPQCEQVD RNIRRVTRAG 360
  361 ILDQIIDMTS YLLDLTSYIV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.39794
Match:	1n7dA
Description:	Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ErbB-2 class receptor binding	5.19651613164447	bayes_pls_golite062009
ErbB-3 class receptor binding	4.63578487982286	bayes_pls_golite062009
receptor binding	3.53758205836051	bayes_pls_golite062009
epidermal growth factor receptor binding	3.23778562911102	bayes_pls_golite062009
growth factor activity	2.87784288183287	bayes_pls_golite062009
binding	2.33940742543305	bayes_pls_golite062009
protein binding	1.97546801934296	bayes_pls_golite062009
glycosaminoglycan binding	1.68773803817361	bayes_pls_golite062009
signal transducer activity	1.66401431847753	bayes_pls_golite062009
molecular transducer activity	1.66401431847753	bayes_pls_golite062009
heparin binding	1.66121757844416	bayes_pls_golite062009
polysaccharide binding	1.45011422686075	bayes_pls_golite062009
pattern binding	1.285853711507	bayes_pls_golite062009
transcription factor binding	0.795087651578297	bayes_pls_golite062009
glycoprotein binding	0.488553067572279	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: