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Protein Overview: PRKRA

General Information:
Name(s) found: PRKRA [HGNC (HUGO)]
Description(s) found:
Found 44 descriptions.
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  • protein kinase, interferon-inducible double stranded RNA dependent activator [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 313 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ  60
   61 IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ 120
  121 PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA 180
  181 KRNAAEKFLA KFSNISPENH ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD 240
  241 YIQLLSEIAK EQGFNITYLD IDELSANGQY QCLAELSTSP ITVCHGSGIS CGNAQSDAAH 300
  301 NALQYLKIIA ERK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] PSI-BLAST 13.522879 No description for 2dixA was found.
    2 View Details [118..195] PSI-BLAST 14.39794 Solution structure of the second dsRBD of TAR RNA-binding protein 2
    3 View Details [196..313] PSI-BLAST 17.154902 dsRNA-dependent protein kinase pkr

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.07736605479017 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  3.47197996469543 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.18496581088988 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.14632751635044 bayes_pls_golite062009
  • siRNA binding
    		•  2.97216972787792 bayes_pls_golite062009
  • structural molecule activity
    		•  2.6585058058337 bayes_pls_golite062009
  • binding
    		•  2.65564350773346 bayes_pls_golite062009
  • protein binding
    		•  2.48364477869915 bayes_pls_golite062009
  • ribonuclease III activity
    		•  2.17541496872253 bayes_pls_golite062009
  • DNA binding
    		•  1.55609377953134 bayes_pls_golite062009
  • protein kinase activity
    		•  1.5033075536308 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.47352121883517 bayes_pls_golite062009
  • kinase activity
    		•  1.3977924791267 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.32350001817922 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.22831298721384 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.19693457490298 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.927536998997123 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.803014306451579 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.755902465799696 bayes_pls_golite062009
  • transferase activity
    		•  0.616475820485559 bayes_pls_golite062009
  • mRNA binding
    		•  0.404665180963566 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.35650576095599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298820022613881 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.0112094156505713 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  5.07736605479017 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  3.47197996469543 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.18496581088988 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.14632751635044 bayes_pls_golite062009
  • siRNA binding
    		•  2.97216972787792 bayes_pls_golite062009
  • structural molecule activity
    		•  2.6585058058337 bayes_pls_golite062009
  • binding
    		•  2.65564350773346 bayes_pls_golite062009
  • protein binding
    		•  2.48364477869915 bayes_pls_golite062009
  • ribonuclease III activity
    		•  2.17541496872253 bayes_pls_golite062009
  • DNA binding
    		•  1.55609377953134 bayes_pls_golite062009
  • protein kinase activity
    		•  1.5033075536308 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.47352121883517 bayes_pls_golite062009
  • kinase activity
    		•  1.3977924791267 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.32350001817922 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.22831298721384 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.19693457490298 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.927536998997123 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.803014306451579 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.755902465799696 bayes_pls_golite062009
  • transferase activity
    		•  0.616475820485559 bayes_pls_golite062009
  • mRNA binding
    		•  0.404665180963566 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.35650576095599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298820022613881 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.0112094156505713 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle