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Protein Overview: PBX3

General Information:
Name(s) found: PBX3 [HGNC (HUGO)]
Description(s) found:
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  • gi|730281|sp|P40426.1|PBX3_HUMAN RecName: Full=Pre-B-cell leukemia transcription factor 3; AltName: Full=Homeobox protein PBX3 [NCBI NR]
  • gi|63100360|gb|AAH94883.1| Pre-B-cell leukemia homeobox 3 [Homo sapiens] [NCBI NR]
  • gi|57162414|emb|CAI40243.1| pre-B-cell leukemia homeobox 3 [Homo sapiens] [NCBI NR]
  • gi|55664586|emb|CAH73695.1| pre-B-cell leukemia homeobox 3 [Homo sapiens] [NCBI NR]
  • gi|5453852|ref|NP_006186.1| pre-B-cell leukemia homeobox 3 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|35315|emb|CAA42502.1| homeobox protein [Homo sapiens] [NCBI NR]
  • gi|119608042|gb|EAW87636.1| pre-B-cell leukemia transcription factor 3, isoform CRA_b [Homo sapiens] [NCBI NR]
  • pir||S19010 homeotic protein PBX3a - human [NCBI NR]
  • pre-B-cell leukemia homeobox 3 [HGNC (HUGO)]
  • Pre-B-cell leukemia transcription factor 3 OS=Homo sapiens GN=PBX3 PE=1 SV=1 [Swiss-Prot]
  • Splice isoform PBX3A of P40426 [hmr_yeast5_DM3-1_pombe.fasta]
  • pre-B-cell leukemia transcription factor 3 [HMR_022704.fasta]
  • pre-B-cell leukemia transcription factor 3 [Homo sapiens]gi|55664586|emb|CAH73695.1| pre-B-cell leukemia transcription factor 3 [Homo sapiens]gi|730281|sp|P40426|PBX3_HUMAN Pre-B-cell leukemia transcription factor-3 (Homeobox protein PBX3)gi|106307|pir [nrdb_11152004_Chlamydomonas]
  • Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform PBX3a of Pre-B-cell leukemia transcription factor 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006195) pre-B-cell leukemia transcription factor 3 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • pre-B-cell leukemia transcription factor 3 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Splice Isoform PBX3a of Pre-B-cell leukemia transcription factor-3 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • pre-B-cell leukemia homeobox 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Pre-B-cell leukemia homeobox 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • pre-B-cell leukemia transcription factor 3, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • homeobox protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform PBX3a of Pre-B-cell leukemia transcription factor 3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • pre-B-cell leukemia homeobox 3 isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PBX3 Isoform PBX3a of Pre-B-cell leukemia transcription factor 3 [human-ipi-250309-contam.fasta]
  • Pre-B-cell leukemia transcription factor 3 [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00028417.1|SWISS-PROT:P40426-1|TREMBL:B7Z4A9|ENSEMBL:ENSP00000362588|REFSEQ:NP_006186|H-INV:HIT000335184|VEGA:OTTHUMP00000022145 Tax_Id=9606 Gene_Symbol=PBX3 Isoform PBX3a of Pre-B-cell leukemia transcription factor 3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • P40426;Q5JSA0;Q5JSA1;Q5VXL3;Q96PF9;Q96PG0; RecName: Full=Pre-B-cell leukemia transcription factor 3; AltName: Full=Homeobox protein PBX3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform PBX3a of Pre-B-cell leukemia transcription factor 3 OS=Homo sapiens GN=PBX3 [011711_HMR.fasta]
  • GeneSymbol=PBX3 Synonyms=- pre-B-cell leukemia transcription factor 3 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Pre-B-cell leukemia transcription factor 3 GN=PBX3 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 434 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS  60
   61 LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV 120
  121 SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH 180
  181 VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR 240
  241 NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300
  301 QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD 360
  361 SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS 420
  421 PTEGPGSVHS DTSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..141] FFAS03 1.07 No description for 2h8rA was found.
    3 View Details [142..228] PSI-BLAST 9.0 THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN
    4 View Details [229..312] PSI-BLAST 18.09691 pbx1
    5 View Details [313..434] MSA 1.768992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle