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Protein Overview: SPTLC2

General Information:
Name(s) found: SPTLC2 [HGNC (HUGO)]
Description(s) found:
Found 35 descriptions.
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  • serine palmitoyltransferase, long chain base subunit 2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 562 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPEPGGCCC RRTVRANGCV ANGEVRNGYV RSSAAAAAAA AAGQIHHVTQ NGGLYKRPFN  60
   61 EAFEETPMLV AVLTYVGYGV LTLFGYLRDF LRYWRIEKCH HATEREEQKD FVSLYQDFEN 120
  121 FYTRNLYMRI RDNWNRPICS VPGARVDIME RQSHDYNWSF KYTGNIIKGV INMGSYNYLG 180
  181 FARNTGSCQE AAAKVLEEYG AGVCSTRQEI GNLDKHEELE ELVARFLGVE AAMAYGMGFA 240
  241 TNSMNIPALV GKGCLILSDE LNHASLVLGA RLSGATIRIF KHNNMQSLEK LLKDAIVYGQ 300
  301 PRTRRPWKKI LILVEGIYSM EGSIVRLPEV IALKKKYKAY LYLDEAHSIG ALGPTGRGVV 360
  361 EYFGLDPEDV DVMMGTFTKS FGASGGYIGG KKELIDYLRT HSHSAVYATS LSPPVVEQII 420
  421 TSMKCIMGQD GTSLGKECVQ QLAENTRYFR RRLKEMGFII YGNEDSPVVP LMLYMPAKIG 480
  481 AFGREMLKRN IGVVVVGFPA TPIIESRARF CLSAAHTKEI LDTALKEIDE VGDLLQLKYS 540
  541 RHRLVPLLDR PFDETTYEET ED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] deduced N/A No confident structure predictions are available.
    2 View Details [123..562] PSI-BLAST 62.69897 2-amino-3-ketobutyrate CoA ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • serine C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  4.29379571948906 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  3.15163480353521 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  2.82458180884712 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.81799375593294 bayes_pls_golite062009
  • threonine aldolase activity
    		•  1.80396420390785 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07873942461292 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.935794708043259 bayes_pls_golite062009
  • DNA binding
    		•  0.886628214497634 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.814403324199462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.811208803619077 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • binding
    		•  0.661198018681765 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • transcription factor activity
    		•  0.615294010373048 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.319452731970428 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.41

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle