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Protein Overview: DHPS

General Information:
Name(s) found: DHPS [HGNC (HUGO)]
Description(s) found:
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  • gi|994715|gb|AAA86282.1| deoxyhypusine synthase [NCBI NR]
  • gi|51247314|pdb|1RQD|B Chain B, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form With The Inhibitor Gc7 Bound In The Active Site [NCBI NR]
  • gi|51247313|pdb|1RQD|A Chain A, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form With The Inhibitor Gc7 Bound In The Active Site [NCBI NR]
  • gi|51247304|pdb|1ROZ|B Chain B, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form [NCBI NR]
  • gi|51247303|pdb|1ROZ|A Chain A, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form [NCBI NR]
  • gi|51247293|pdb|1RLZ|A Chain A, Deoxyhypusine Synthase Holoenzyme In Its High Ionic Strength, Low Ph Crystal Form [NCBI NR]
  • gi|4503325|ref|NP_001921.1| deoxyhypusine synthase isoform a [Homo sapiens] [NCBI NR]
  • gi|3021398|emb|CAA04940.1| deoxyhypusine synthase [Homo sapiens] [NCBI NR]
  • gi|1710220|gb|AAB50208.1| deoxyhypusine synthase [Homo sapiens] [NCBI NR]
  • gi|158256538|dbj|BAF84242.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|15559312|gb|AAH14016.1| Deoxyhypusine synthase [Homo sapiens] [NCBI NR]
  • gi|1352267|sp|P49366.1|DHYS_HUMAN RecName: Full=Deoxyhypusine synthase; Short=DHS [NCBI NR]
  • gi|12653133|gb|AAH00333.1| Deoxyhypusine synthase [Homo sapiens] [NCBI NR]
  • gi|119604699|gb|EAW84293.1| deoxyhypusine synthase, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119604694|gb|EAW84288.1| deoxyhypusine synthase, isoform CRA_b [Homo sapiens] [NCBI NR]
  • deoxyhypusine synthase [HGNC (HUGO)]
  • Deoxyhypusine synthase OS=Homo sapiens GN=DHPS PE=1 SV=1 [Swiss-Prot]
  • Splice isoform Long of P49366 [hmr_yeast5_DM3-1_pombe.fasta]
  • deoxyhypusine synthase isoform a [HMR_022704.fasta]
  • deoxyhypusine synthase isoform a [Homo sapiens]gi|12653133|gb|AAH00333.1| Deoxyhypusine synthase, isoform a [Homo sapiens]gi|15559312|gb|AAH14016.1| Deoxyhypusine synthase, isoform a [Homo sapiens]gi|51247314|pdb|1RQD|B Chain B, Deoxyhypusine Synthase [nrdb_11152004_Chlamydomonas]
  • Deoxyhypusine synthase (DHS) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Long of Deoxyhypusine synthase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001930) deoxyhypusine synthase isoform a [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • deoxyhypusine synthase isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Chain B, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form With The Inhibitor Gc7 Bound In The Active Site [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form With The Inhibitor Gc7 Bound In The Active Site [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Deoxyhypusine Synthase Holoenzyme In Its Low Ionic Strength, High Ph Crystal Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Deoxyhypusine Synthase Holoenzyme In Its High Ionic Strength, Low Ph Crystal Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • deoxyhypusine synthase, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • deoxyhypusine synthase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Deoxyhypusine synthase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform Long of Deoxyhypusine synthase [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF DEOXYHYPUSINE SYNTHASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Deoxyhypusine synthase; Short=DHS [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=DHPS Isoform Long of Deoxyhypusine synthase [human-ipi-250309-contam.fasta]
  • IPI:IPI00026829.1|SWISS-PROT:P49366-1|TREMBL:A8K688|ENSEMBL:ENSP00000210060|REFSEQ:NP_001921|H-INV:HIT000295800|VEGA:OTTHUMP00000076354 Tax_Id=9606 Gene_Symbol=DHPS Isoform Long of Deoxyhypusine synthase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=DHPS Isoform Long of Deoxyhypusine synthase ENSG00000095059 IPI00026829 IPI00215771 IPI00375406 IPI00552707 [drosphohumanreversed.fasta]
  • P49366;A8K688;Q13184;Q13276;Q9UDG0; RecName: Full=Deoxyhypusine synthase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform Long of Deoxyhypusine synthase OS=Homo sapiens GN=DHPS [011711_HMR.fasta]
  • IPI:IPI00026829.1|SWISS-PROT:P49366-1|ENSEMBL:ENSP00000210060|REFSEQ:NP_001921|H-INV:HIT000295800|VEGA:OTTHUMP00000076354 Tax_Id=9606 Gene_Symbol=DHPS Isoform Long of Deoxyhypusine synthase [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=DHPS Synonyms=DHS|DS|MIG13 deoxyhypusine synthase isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00026829.1|SWISS-PROT:P49366-1|ENSEMBL:ENSP00000210060|REFSEQ:NP_001921|H-INV:HIT000295800 Tax_Id=9606 Gene_Symbol=DHPS Isoform Long of Deoxyhypusine synthase [ipi.HUMAN.20110912.fasta]
  • Deoxyhypusine synthase GN=DHPS [Doctor+uniprot-HUMAN-120911.fasta]
  • Deoxyhypusine synthase, isoform CRA_b OS=Homo sapiens GN=DHPS PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 369 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG  60
   61 RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV 120
  121 QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE 180
  181 DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS 240
  241 LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA 300
  301 DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD 360
  361 AFMHEKNED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..369] PSI-BLAST 1000.0 Deoxyhypusine synthase holoenzyme in its high ionic strength, low pH crystal form

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • deoxyhypusine synthase activity
    		•  4.8590235726137 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.51117258094456 bayes_pls_golite062009
  • protein deacetylase activity
    		•  2.11398191156761 bayes_pls_golite062009
  • DNA binding
    		•  2.09930834951157 bayes_pls_golite062009
  • histone deacetylase activity
    		•  2.08718650273166 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00972611627502 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • deacetylase activity
    		•  1.15111805612466 bayes_pls_golite062009
  • transcription factor binding
    		•  1.07103864164531 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0180828203704 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.516307124442946 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.42635585193838 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.23414654967509 bayes_pls_golite062009
  • hydrolase activity
    		•  0.169696911903799 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle