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Protein Overview: DID4

General Information:
Name(s) found: DID4 / YKL002W [SGD]
Description(s) found:
Found 9 descriptions.
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  • Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 151 amino acids

    Gene Ontology:
    Cellular Component: ESCRT III complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    late endosome to vacuole transport [IPILink to PubMed article]
    Molecular Function: protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAQLQAISL RIQAVRSSDQ MTRSMSEATG LLAGMNRTMN LPQLQRISME FEKQSDLMGQ  60
   61 RQEFMDEAID NVMGDEVDED EEADEIVNKV LDEIGVDLNS QLQSTPQNLV SNAPIAETAM 120
  121 GIPEPIGAGS EFHGNPDDDL QARLNTLKKQ T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] Pfam 68.30103 ESCRT-III complex subunit No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle