Protein Overview: PRS4

General Information:
Name(s) found:	PRS4 / YBL068W [SGD]
Description(s) found: Found 15 descriptions. SHOW ALL	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [SGD]
Organism:	Saccharomyces cerevisiae
Length:	327 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	'de novo' pyrimidine base biosynthetic process [TAS] tryptophan biosynthetic process [TAS] 'de novo' IMP biosynthetic process [TAS] ribosome biogenesis [RCA] histidine biosynthetic process [TAS] purine ribonucleoside salvage [TAS]
Molecular Function:	ribose phosphate diphosphokinase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSESREDMA INSIKLLAGN SHPDLAEQIS KKLGIPLSKV GVYQYSNKET SVTIGESLRD  60
   61 EDVYIIQTGI GEQEINDFLM ELLILIHACQ IASARKITTV IPNFPYARQD KKDKSRAPIT 120
  121 AKLVANLLQT AGADHVITMD LHASQIQGFF HIPVDNLYAE PSVLNYIRAR KTDFDNAILV 180
  181 SPDAGGAKRV AALADKLDLN FALIHKERQK ANEVSKMVLV GDVTNKSCLL VDDMADTCGT 240
  241 LVKACDTLME HGAKEVIAIV THGIFSGSAR EKLRNSRLSR IVCTNTVPVD LDLPIADQID 300
  301 ISPTFAEAIR RLHNGESVSY LFTHAPV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		PRS1 PRS4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PEX10	PRS4	1	Unpublished Fields Lab Data
View Screen	NTA1	PRS4	1	Unpublished Fields Lab Data
View Screen	UBC7	PRS4	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PRS4	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..327]	PSI-BLAST	91.0	Phosphoribosylpyrophosphate synthetase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2