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Protein Overview: USP8

General Information:
Name(s) found: USP8 [HGNC (HUGO)]
Description(s) found:
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  • gi|83405557|gb|AAI10591.1| Ubiquitin specific peptidase 8 [Homo sapiens] [NCBI NR]
  • gi|731046|sp|P40818.1|UBP8_HUMAN RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=Ubiquitin thioesterase 8; AltName: Full=Ubiquitin-specific-processing protease 8; AltName: Full=Deubiquitinating enzyme 8; Short=hUBPy [NCBI NR]
  • gi|190684694|ref|NP_001122083.1| ubiquitin specific peptidase 8 [Homo sapiens] [NCBI NR]
  • gi|190684692|ref|NP_001122082.1| ubiquitin specific peptidase 8 [Homo sapiens] [NCBI NR]
  • gi|190684690|ref|NP_005145.3| ubiquitin specific peptidase 8 [Homo sapiens] [NCBI NR]
  • gi|119597807|gb|EAW77401.1| ubiquitin specific peptidase 8, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119597806|gb|EAW77400.1| ubiquitin specific peptidase 8, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119597805|gb|EAW77399.1| ubiquitin specific peptidase 8, isoform CRA_a [Homo sapiens] [NCBI NR]
  • ubiquitin specific peptidase 8 [HGNC (HUGO)]
  • Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens GN=USP8 PE=1 SV=1 [Swiss-Prot]
  • [hmr_yeast5_DM3-1_pombe.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 8 [hmr_yeast5_DM3-1_pombe.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 8 (Ubiquitin thiolesterase 8) (Ubiquitin-specific processing protease 8) (Deubiquitinating enzyme 8) (hUBPy) [nrdb_11152004_Chlamydomonas]
  • [pompep4896_normal_reversed]
  • Tax_Id=9606 Ubiquitin carboxyl-terminal hydrolase 8 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005154) ubiquitin specific protease 8 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Ubiquitin specific peptidase 8 [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • ubiquitin specific peptidase 8 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 8 (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ubiquitin specific peptidase 8, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=Ubiquitin thioesterase 8; AltName: Full=Ubiquitin-specific-processing protease 8; AltName: Full=Deubiquitinating enzyme 8; Short=hUBPy [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=USP8 Ubiquitin carboxyl-terminal hydrolase 8 [human-ipi-250309-contam.fasta]
  • IPI:IPI00030915.1|SWISS-PROT:P40818|TREMBL:A8K8N5;Q05CD9;Q05DF5|ENSEMBL:ENSP00000302239;ENSP00000379721;ENSP00000405537|REFSEQ:NP_001122082;NP_001122083;NP_005145|H-INV:HIT000042205|VEGA:OTTHUMP00000162416;OTTHUMP00000175806 Tax_Id=9606 Gene_Symbol=USP8 U [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Gene_Symbol=USP8 Ubiquitin carboxyl-terminal hydrolase 8 ENSG00000138592 IPI00030915 IPI00795824 IPI00796539 [drosphohumanreversed.fasta]
  • ubiquitin carboxyl-terminal hydrolase 8 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P40818;Q2TB31;Q7Z3U2;Q86VA0;Q8IWI7; RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; AltName: Full=Ubiquitin thioesterase 8; AltName: Full=Ubiquitin-specific-processing protease 8; AltName: Full=Deubiquitinating enzyme 8; AltName: Full=Ubiquitin isopeptidase Y; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens GN=USP8 [011711_HMR.fasta]
  • IPI:IPI00030915.1|SWISS-PROT:P40818|TREMBL:A8K8N5;Q05CD9;Q05DF5|ENSEMBL:ENSP00000302239;ENSP00000379721;ENSP00000405537|REFSEQ:NP_001122082;NP_001122083;NP_005145|H-INV:HIT000042205|VEGA:OTTHUMP00000162416;OTTHUMP00000175806 Tax_Id=9606 Gene_Symbol=USP8 Ubiquitin carboxyl-terminal hydrolase 8 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=USP8 Synonyms=FLJ34456|HumORF8|KIAA0055|MGC129718|UBPY ubiquitin carboxyl-terminal hydrolase 8 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00030915.1|SWISS-PROT:P40818|TREMBL:A8K8N5;Q05CD9;Q05DF5|ENSEMBL:ENSP00000302239;ENSP00000379721;ENSP00000405537|REFSEQ:NP_001122082;NP_001122083;NP_005145|H-INV:HIT000042205|VEGA:OTTHUMP00000162416 Tax_Id=9606 Gene_Symbol=USP8 Ubiquitin carboxyl-terminal hydrolase 8 [ipi.HUMAN.20110912.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 8 GN=USP8 [Doctor+uniprot-HUMAN-120911.fasta]
  • Ubiquitin carboxyl-terminal hydrolase OS=Homo sapiens GN=USP8 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 1118 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY  60
   61 VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK 120
  121 KLEEKDRQEE AQRLQQKRQE TGREDGGTLA KGSLENVLDS KDKTQKSNGE KNEKCETKEK 180
  181 GAITAKELYT MMTDKNISLI IMDARRMQDY QDSCILHSLS VPEEAISPGV TASWIEAHLP 240
  241 DDSKDTWKKR GNVEYVVLLD WFSSAKDLQI GTTLRSLKDA LFKWESKTVL RNEPLVLEGG 300
  301 YENWLLCYPQ YTTNAKVTPP PRRQNEEVSI SLDFTYPSLE ESIPSKPAAQ TPPASIEVDE 360
  361 NIELISGQNE RMGPLNISTP VEPVAASKSD VSPIIQPVPS IKNVPQIDRT KKPAVKLPEE 420
  421 HRIKSESTNH EQQSPQSGKV IPDRSTKPVV FSPTLMLTDE EKARIHAETA LLMEKNKQEK 480
  481 ELRERQQEEQ KEKLRKEEQE QKAKKKQEAE ENEITEKQQK AKEEMEKKES EQAKKEDKET 540
  541 SAKRGKEITG VKRQSKSEHE TSDAKKSVED RGKRCPTPEI QKKSTGDVPH TSVTGDSGSG 600
  601 KPFKIKGQPE SGILRTGTFR EDTDDTERNK AQREPLTRAR SEEMGRIVPG LPSGWAKFLD 660
  661 PITGTFRYYH SPTNTVHMYP PEMAPSSAPP STPPTHKAKP QIPAERDREP SKLKRSYSSP 720
  721 DITQAIQEEE KRKPTVTPTV NRENKPTCYP KAEISRLSAS QIRNLNPVFG GSGPALTGLR 780
  781 NLGNTCYMNS ILQCLCNAPH LADYFNRNCY QDDINRSNLL GHKGEVAEEF GIIMKALWTG 840
  841 QYRYISPKDF KITIGKINDQ FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH 900
  901 LDDFKAAEHA WQKHKQLNES IIVALFQGQF KSTVQCLTCH KKSRTFEAFM YLSLPLASTS 960
  961 KCTLQDCLRL FSKEEKLTDN NRFYCSHCRA RRDSLKKIEI WKLPPVLLVH LKRFSYDGRW1020
 1021 KQKLQTSVDF PLENLDLSQY VIGPKNNLKK YNLFSVSNHY GGLDGGHYTA YCKNAARQRW1080
 1081 FKFDDHEVSD ISVSSVKSSA AYILFYTSLG PRVTDVAT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 11.522879 Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
    2 View Details [145..314] FFAS03 4.23 Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)
    3 View Details [315..530] deduced N/A No confident structure predictions are available.
    4 View Details [531..718] deduced N/A No confident structure predictions are available.
    5 View Details [719..1118] PSI-BLAST 117.0 No description for 2gfoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.7573477158791 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.711045884031031 bayes_pls_golite062009
  • catalytic activity
    		•  0.660280721417663 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.514129714366787 bayes_pls_golite062009
  • protein binding
    		•  0.512164575740487 bayes_pls_golite062009
  • transferase activity
    		•  0.24413644201982 bayes_pls_golite062009
  • phosphatase activity
    		•  0.0126182055752568 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle