Protein Overview: TAZ1

General Information:
Name(s) found:	TAZ1 / YPR140W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6325398\|ref\|NP_015466.1\| Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Bart [NCBI NR] gi\|59800388\|sp\|Q06510.1\|TAZ1_YEAST RecName: Full=Lysophosphatidylcholine acyltransferase; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=lyso-PC acyltransferase; AltName: Full=Tafazzin homolog [NCBI NR] gi\|1066481\|gb\|AAB68280.1\| Ypr140wp [Saccharomyces cerevisiae] [NCBI NR] Lysophosphatidylcholine acyltransferase OS=Saccharomyces cerevisiae GN=TAZ1 PE=1 SV=1 [Swiss-Prot] TAZ1 Protein is required for normal phospholipid content of mitochondrial membranes [mips] Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome [SGD] >Q06510 (Q06510) Chromosome XVI COSMID 9659 [4932.FASTACCERV.txt] Chr XVI from 814385-815530 [hmr_yeast5_DM3-1_pombe.fasta] Chr XVI from 814386-815531 [yeastorf3.fasta] YPR140W, Chr XVI from 814386-815531 [yeast_orfs2] TAZ1 SGDID:S0006344, Chr XVI from 814385-815530, Verified ORF [yeastflysequest.fasta] TAZ1 SGDID:S0006344, Chr XVI from 814387-815532, Verified ORF [10112005cervSGD.fasta] Putative acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel the acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome [Saccharomyces cerevisiae]gi [nrdb_11152004_Chlamydomonas] (Q06510) Ypr140wp [cerv4932.FASTAC] TAZ1 SGDID:S000006344, Chr XVI from 814387-815532, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TAZ1 SGDID:S000006344, Chr XVI from 814387-815532, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog t [yeast-200209-contam.fasta] Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome; Taz1p [Saccharom [nr-271106-contam.fasta] Tafazzin homolog [nr-271106-contam.fasta] Ypr140wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TAZ1 SGDID:S000006344, Chr XVI from 814387-815532, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome" [yeast-bovrabprots.fasta] TAZ1 SGDID:S000006344, Chr XVI from 814387-815532, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome" [yeast-contam_custom.fasta] [chemostatdb.fasta] Lysophosphatidylcholine acyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAZ1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TAZ1 SGDID:S000006344, Chr XVI from 814391-815536, Genome Release 64-1-1, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome" [yeast-030211-contam.fasta] TAZ1 SGDID:S000006344, Chr XVI from 814391-815536, Genome Release 64-2-1, Verified ORF, "Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia" [20141208_orf_trans.fasta] YPR140W SGDID:S000006344, Chr XVI from 814391-815536, Genome Release 64-1-1, Verified ORF, "Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	381 amino acids
Gene Ontology:
Cellular Component:	integral to mitochondrial outer membrane [IDA] mitochondrion [IDA ]
Biological Process:	positive regulation of gene-specific transcription [IMP] protein complex assembly [IMP] phospholipid biosynthetic process [IMP ] cardiolipin metabolic process [IMP] inner mitochondrial membrane organization [IMP] mitochondrial ATP synthesis coupled electron transport [IMP]
Molecular Function:	1-acylglycerophosphocholine O-acyltransferase activity [IEA][IMP] transferase activity [IEA] acyltransferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFRDVLERG DEFLEAYPRR SPLWRFLSYS TSLLTFGVSK LLLFTCYNVK LNGFEKLETA  60
   61 LERSKRENRG LMTVMNHMSM VDDPLVWATL PYKLFTSLDN IRWSLGAHNI CFQNKFLANF 120
  121 FSLGQVLSTE RFGVGPFQGS IDASIRLLSP DDTLDLEWTP HSEVSSSLKK AYSPPIIRSK 180
  181 PSWVHVYPEG FVLQLYPPFE NSMRYFKWGI TRMILEATKP PIVVPIFATG FEKIASEAVT 240
  241 DSMFRQILPR NFGSEINVTI GDPLNDDLID RYRKEWTHLV EKYYDPKNPN DLSDELKYGK 300
  301 EAQDLRSRLA AELRAHVAEI RNEVRKLPRE DPRFKSPSWW KRFNTTEGKS DPDVKVIGEN 360
  361 WAIRRMQKFL PPEGKPKGKD D

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AI1 LTE1 TAZ1
View Details	Qiu et al. (2008)		ATP6 ATP8 COB COX1 COX2 COX3 COX5B CYT1 MCR1 OLI1 TAZ1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MCD1	TAZ1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TAZ1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..329]	PSI-BLAST	2.39794	Glycerol-3-phosphate (1)-acyltransferase
2	View Details	[330..381]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.58

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2