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Protein Overview: MRL1

General Information:
Name(s) found: MRL1 / YPR079W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 381 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    late endosome [IDALink to PubMed article]
    Biological Process: vacuolar transport [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: signal sequence binding [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDED  60
   61 LFCAVTNPVT GSYIDLSQLS STPNKLREGQ KQISGNNKHE SSKTKWSVRG WGYDTNFTLG 120
  121 ICSSPVGEAE SQQLSNLTGA FYVDQLNENN LVSIGDFSTR PALVGGSTAK KLTLKYENGS 180
  181 MCPNGKDKKA TLLNFVCDKE IQSKAQISYI GNLHNCSYFF EVRSIHACPT SNKKNEVNVL 240
  241 GIFIGIFAIF FLVEFAGRRW IYAKLNRHLK NDDELHDISP SLNEQPHWDL IEDGSRWSKF 300
  301 FNGIIKTTRR FTKSLMRSLV RGRNSRQGGI RLRSSPSASS SSLANREFFR DMEAQNEIID 360
  361 SLDINSHTTE SDHPTLADNS V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MRL1 PIB2 VTH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGT2 MRL1 2 Unpublished Fields Lab Data
    View Screen CTF13 MRL1 1 Unpublished Fields Lab Data
    View Screen CUS1 MRL1 1 Unpublished Fields Lab Data
    View Screen ARE2 MRL1 1 Unpublished Fields Lab Data
    View Screen RAD54 MRL1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MRL1 Huh WK, et al. (2003)
    View Data MRL1 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59] deduced N/A No confident structure predictions are available.
    2 View Details [60..229] PSI-BLAST 27.39794 Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
    3 View Details [230..381] PSI-BLAST 24.0 Cation-independent mannose-6-phosphate receptor (MIR-receptor)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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