YRC Public Data Repository - Protein Structure Prediction

Protein:	MRL1
Organism:	Saccharomyces cerevisiae
Length:	381 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRL1.

Description	E-value	Query Range	Subject Range
MRL1 - Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a... gi\|190408012 - gi\|190408012\|gb\|EDV11277.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] MRL1_YEAST - Mannose 6-phosphate receptor-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...	4.0E-97	[1..381]	[1..381]
gi\|225000712 - gi\|225000712\|gb\|AAI72256.1\| Insulin-like growth factor 2 receptor [synthetic construct] IGF2R - insulin-like growth factor 2 receptor	3.0E-75	[3..376]	[1324..1666]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-75	[3..376]	[1324..1666]
gi\|14647155 - gi\|14647155\|gb\|AAK71869.1\|AF339163_1 mannose-6-phosphate/insulin-like growth factor II receptor [Cyn...	2.0E-73	[3..376]	[1270..1612]
MPRI_BOVIN - Cation-independent mannose-6-phosphate receptor OS=Bos taurus GN=IGF2R PE=1 SV=2	2.0E-73	[3..376]	[1333..1675]
gi\|14647151 - gi\|14647151\|gb\|AAK71867.1\|AF339161_1 mannose-6-phosphate/insulin-like growth factor II receptor [Tup...	3.0E-73	[3..376]	[1271..1613]
gi\|1398935, gi\|6... - gi\|6981078\|ref\|NP_036888.1\| insulin-like growth factor 2 receptor [Rattus norvegicus], gi\|1398935\|gb...	9.0E-73	[3..376]	[1313..1655]

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Predicted Domain #1

Region A:
Residues: [1-59]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [60-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLFCAVTNPV TGSYIDLSQL SSTPNKLREG QKQISGNNKH ESSKTKWSVR GWGYDTNFTL  60
   61 GICSSPVGEA ESQQLSNLTG AFYVDQLNEN NLVSIGDFST RPALVGGSTA KKLTLKYENG 120
  121 SMCPNGKDKK ATLLNFVCDK EIQSKAQISY IGNLHNCSYF FEVRSIHACP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1c39A_
Description:	Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [230-381]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSNKKNEVNV LGIFIGIFAI FFLVEFAGRR WIYAKLNRHL KNDDELHDIS PSLNEQPHWD  60
   61 LIEDGSRWSK FFNGIIKTTR RFTKSLMRSL VRGRNSRQGG IRLRSSPSAS SSSLANREFF 120
  121 RDMEAQNEII DSLDINSHTT ESDHPTLADN SV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.0
Match:	1e6fA_
Description:	Cation-independent mannose-6-phosphate receptor (MIR-receptor)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits