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View Structure Prediction Details

Protein: MRL1
Organism: Saccharomyces cerevisiae
Length: 381 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRL1.

Description E-value Query
Range
Subject
Range
MRL1 - Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a...
gi|190408012 - gi|190408012|gb|EDV11277.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
MRL1_YEAST - Mannose 6-phosphate receptor-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
4.0E-97 [1..381] [1..381]
gi|225000712 - gi|225000712|gb|AAI72256.1| Insulin-like growth factor 2 receptor [synthetic construct]
IGF2R - insulin-like growth factor 2 receptor
3.0E-75 [3..376] [1324..1666]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-75 [3..376] [1324..1666]
gi|14647155 - gi|14647155|gb|AAK71869.1|AF339163_1 mannose-6-phosphate/insulin-like growth factor II receptor [Cyn...
2.0E-73 [3..376] [1270..1612]
MPRI_BOVIN - Cation-independent mannose-6-phosphate receptor OS=Bos taurus GN=IGF2R PE=1 SV=2
2.0E-73 [3..376] [1333..1675]
gi|14647151 - gi|14647151|gb|AAK71867.1|AF339161_1 mannose-6-phosphate/insulin-like growth factor II receptor [Tup...
3.0E-73 [3..376] [1271..1613]
gi|1398935, gi|6... - gi|6981078|ref|NP_036888.1| insulin-like growth factor 2 receptor [Rattus norvegicus], gi|1398935|gb...
9.0E-73 [3..376] [1313..1655]

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Predicted Domain #1
Region A:
Residues: [1-59]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.269 a.4.5 "Winged helix" DNA-binding domain
View Download 0.316 a.4.1 Homeodomain-like
View Download 0.272 a.77.1 DEATH domain
View Download 0.263 a.50.1 Anaphylotoxins (complement system)
View Download 0.289 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.245 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.234 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.203 a.35.1 lambda repressor-like DNA-binding domains

Predicted Domain #2
Region A:
Residues: [60-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLFCAVTNPV TGSYIDLSQL SSTPNKLREG QKQISGNNKH ESSKTKWSVR GWGYDTNFTL  60
   61 GICSSPVGEA ESQQLSNLTG AFYVDQLNEN NLVSIGDFST RPALVGGSTA KKLTLKYENG 120
  121 SMCPNGKDKK ATLLNFVCDK EIQSKAQISY IGNLHNCSYF FEVRSIHACP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.39794
Match: 1c39A_
Description: Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [230-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSNKKNEVNV LGIFIGIFAI FFLVEFAGRR WIYAKLNRHL KNDDELHDIS PSLNEQPHWD  60
   61 LIEDGSRWSK FFNGIIKTTR RFTKSLMRSL VRGRNSRQGG IRLRSSPSAS SSSLANREFF 120
  121 RDMEAQNEII DSLDINSHTT ESDHPTLADN SV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1e6fA_
Description: Cation-independent mannose-6-phosphate receptor (MIR-receptor)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle