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Protein Overview: COX10

General Information:
Name(s) found: COX10 / YPL172C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: heme a biosynthetic process [IMPLink to PubMed article]
    Molecular Function: protoheme IX farnesyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH GGKQQHINTA  60
   61 PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG SEATTDASTQ LPFNVKLVDP 120
  121 MVRKSKRPSH AISEGLNMKT LKKKVIMPYL QLTKPRLTIL VMLSAICSYA LSPYPASVNE 180
  181 LLCLTVGTTL CSGSANAINM GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV 240
  241 SILYFGVNPT VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH 300
  301 PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL RYSILMFPLC 360
  361 FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS AKTLKDNVKF NKGLSVANIY 420
  421 ARKTFMASVL HLPAILILAI IHKKGRWDWI YPGEAKRPQE RF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COX10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] MSA 1.03499 View MSA. No confident structure predictions are available.
    2 View Details [84..154] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [155..462] Pfam 71.568636 UbiA prenyltransferase family No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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