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Protein Overview: MET7

General Information:
Name(s) found: MET7 / YOR241W [SGD]
Description(s) found:
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  • gi|6324815|ref|NP_014884.1| Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; Met7p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013087|gb|AAT92837.1| YOR241W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2494590|sp|Q08645.1|FOLE_YEAST RecName: Full=Folylpolyglutamate synthase; AltName: Full=Folylpoly-gamma-glutamate synthetase; Short=FPGS; AltName: Full=Tetrahydrofolylpolyglutamate synthase; Short=Tetrahydrofolate synthase [NCBI NR]
  • pir||S67134 probable membrane protein YOR241w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420550|emb|CAA99462.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Folylpolyglutamate synthase OS=Saccharomyces cerevisiae GN=MET7 PE=1 SV=1 [Swiss-Prot]
  • MET7 Tetrahydrofolylpolyglutamate synthase [mips]
  • Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA [SGD]
  • (Q08645) Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) [4932.FASTACCERV.txt]
  • Chr XV from 786995-788641 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 786994-788640 [yeastorf3.fasta]
  • MET7, Chr XV from 786994-788640 [yeast_orfs2]
  • MET7 SGDID:S0005767, Chr XV from 786995-788641, Verified ORF [yeastflysequest.fasta]
  • Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA, present in both the cytoplasm and mitochondria [Saccharomyces cerevisiae]gi|51 [nrdb_11152004_Chlamydomonas]
  • MET7 SGDID:S000005767, Chr XV from 786995-788641, Verified ORF, "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA, present in bot [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MET7 SGDID:S000005767, Chr XV from 786996-788642, Verified ORF, "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA" [yeast-contam.fasta]
  • Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; Met7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Folylpolyglutamate synthase (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase) [nr-271106-contam.fasta]
  • YOR241W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MET7 SGDID:S000005767, Chr XV from 786995-788641, Genome Release 64-1-1, Verified ORF, "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA" [yeast-030211-contam.fasta]
  • MET7 SGDID:S000005767, Chr XV from 786995-788641, Genome Release 64-2-1, Verified ORF, "Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YOR241W SGDID:S000005767, Chr XV from 786995-788641, Genome Release 64-1-1, Verified ORF, "Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    one-carbon metabolic process [IMPLink to PubMed article]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKGKKNYPN LITSFRMNLK KIILNHDRFS HPERWKTNAL LRFTFVYIKF LFDLMIIKNP  60
   61 LRMVGKTYRD AVTALNSLQS NYANIMAIRQ TGDRKNTMTL LEMHEWSRRI GYSASDFNKL 120
  121 NIVHITGTKG KGSTAAFTSS ILGQYKEQLP RIGLYTSPHL KSVRERIRIN GEPISEEKFA 180
  181 KYFFEVWDRL DSTTSSLDKF PHMIPGSKPG YFKFLTLLSF HTFIQEDCKS CVYEVGVGGE 240
  241 LDSTNIIEKP IVCGVTLLGI DHTFMLGDTI EEIAWNKGGI FKSGAPAFTV EKQPPQGLTI 300
  301 LKERAEERKT TLTEVPPFKQ LENVKLGIAG EFQKSNASLA VMLASEILHT SNILEEKIKC 360
  361 SSNASIPEKF IIGLQNTKWE GRCQVLEKGK NVWYIDGAHT KDSMVAASTW FRDMVRLSKR 420
  421 KKILLFNQQS RDANALVNNL YSSVSPEITF DDVIFTTNVT WKSGSYSADL VSMNTSQEDV 480
  481 EKLKVQESLV KNWNKIDDNR AKTHVTASIE EANELIETLY DEPADIFVTG SLHLVGGLLV 540
  541 VFDRIDVK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MET7 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] deduced N/A No confident structure predictions are available.
    2 View Details [98..379] PSI-BLAST 275.38764 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
    3 View Details [380..548] PSI-BLAST 275.38764 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle