YRC Public Data Repository - Protein Structure Prediction

Protein:	MET7
Organism:	Saccharomyces cerevisiae
Length:	548 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET7.

Description	E-value	Query Range	Subject Range
FOLE_YEAS8 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) GN=... FOLE_YEAS7 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain YJM789) GN=MET7 PE=3 SV=1 FOLE_YEAST - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET7 PE=1 SV... FOLE_YEASL - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Lalvin QA23) GN=MET7 PE=3 SV=2 MET7 - Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, ... FOLE_YEAS1 - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=MET7 PE=3 SV=1 FOLE_YEASZ - Folylpolyglutamate synthase OS=Saccharomyces cerevisiae (strain Zymaflore VL3) GN=MET7 PE=3 SV=2	0.0	[1..548]	[1..548]
FOLE_SCHPO - Probable folylpolyglutamate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=met7 ... SPBC1709.17 - folylpolyglutamate synthase	2.0E-90	[48..545]	[7..503]
FOLE_CANAX - Folylpolyglutamate synthase OS=Candida albicans GN=MET7 PE=3 SV=1	4.0E-86	[66..543]	[16..510]
FPGS - folylpolyglutamate synthase	2.0E-85	[66..545]	[43..584]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-84	[65..543]	[42..582]
gi\|14582587 - gi\|14582587\|gb\|AAK69546.1\|AF283647_1 folylpoly-gammaglutamate synthetase precursor [Cricetulus grise...	1.0E-83	[65..543]	[42..582]
gi\|13529530 - gi\|13529530\|gb\|AAH05484.1\| Fpgs protein [Mus musculus]	1.0E-82	[66..543]	[1..540]

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Predicted Domain #1

Region A:
Residues: [1-97]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKGKKNYPN LITSFRMNLK KIILNHDRFS HPERWKTNAL LRFTFVYIKF LFDLMIIKNP  60
   61 LRMVGKTYRD AVTALNSLQS NYANIMAIRQ TGDRKNT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [98-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLEMHEWS RRIGYSASDF NKLNIVHITG TKGKGSTAAF TSSILGQYKE QLPRIGLYTS  60
   61 PHLKSVRERI RINGEPISEE KFAKYFFEVW DRLDSTTSSL DKFPHMIPGS KPGYFKFLTL 120
  121 LSFHTFIQED CKSCVYEVGV GGELDSTNII EKPIVCGVTL LGIDHTFMLG DTIEEIAWNK 180
  181 GGIFKSGAPA FTVEKQPPQG LTILKERAEE RKTTLTEVPP FKQLENVKLG IAGEFQKSNA 240
  241 SLAVMLASEI LHTSNILEEK IKCSSNASIP EKFIIGLQNT KW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	275.38764
Match:	1fgs__
Description:	Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [380-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRCQVLEKG KNVWYIDGAH TKDSMVAAST WFRDMVRLSK RKKILLFNQQ SRDANALVNN  60
   61 LYSSVSPEIT FDDVIFTTNV TWKSGSYSAD LVSMNTSQED VEKLKVQESL VKNWNKIDDN 120
  121 RAKTHVTASI EEANELIETL YDEPADIFVT GSLHLVGGLL VVFDRIDVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	275.38764
Match:	1fgs__
Description:	Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits